DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SPOP_SBC_1

Location: 145:149

E3 ligase: SPOP

DEGRON score: 0.9158

ASA_SCORE: 90.36

COIL: 0.95

CONS_SCORE: 1

DSS_SCORE: 0.4956

HELIX: 0.0306

FCONS_SCORE: 1.1533

RIG_SCORE: 0.6778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E143D	TCGA-55-1592	LUAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.2778
p.E143D	DO23556	LUAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.2778
p.S148T	TCGA-AZ-4315	COAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.6005
p.S148T	DO8842	COAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.6005
p.S149Y	TCGA-AZ-4315	COAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.712
p.S149Y	DO8842	COAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.712
p.N144Y	TCGA-BP-4161	KIRC	TCGA	VNTSS	DEG_SPOP_SBC_1	0.3056
p.N144Y	DO17769	KIRC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.3056
p.N158D	DO233840	GACA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.V157L	DO229041	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1111
p.A136D	SIDM02075	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.T137I	SIDM01307	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.1111
p.V151A	ACH-000991	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.2778
p.V151A	SNU-81	large_intestine	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09619	Platelet-derived growth factor receptor beta	DEG_SPOP_SBC_1	1052:1056	VNTSS	SPOP	0.9079	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	369:373	VNTSS	SPOP	0.9386	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	145:149	VNTSS	SPOP	0.9158	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	221:225	VNTSS	SPOP	0.9787	More...
Q9H6R7	WD repeat and coiled-coil-containing protein	DEG_SPOP_SBC_1	482:486	VNTSS	SPOP	0.7588	More...
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_SPOP_SBC_1	154:158	VNTSS	SPOP	0.9935	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	456:460	VNTSS	SPOP	0.7805	More...
Q6Q759	Sperm-associated antigen 17	DEG_SPOP_SBC_1	11:15	VNTSS	SPOP	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons