DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: DEG_SPOP_SBC_1

Location: 11:15

E3 ligase: SPOP

DEGRON score: 0.8744

ASA_SCORE: 80.72

COIL: 0.8586

CONS_SCORE: 0.3261

DSS_SCORE: 0.4696

HELIX: 0.1256

FCONS_SCORE: 0.8544

RIG_SCORE: 0.7312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S15Y	TCGA-AA-3510	COAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.712
p.S15Y	DO7783	COAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.712
p.S15Y	SIDM00193	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.712
p.S15Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.712
p.S15Y	SNU-81	large_intestine	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.712
p.A2V	TCGA-IB-7651	PAAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.0833
p.A2V	DO46657	PAAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.K5N	DO225230	BRCA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.2778
p.L22I	DO229019	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1389
p.P20H	DO229015	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1944
p.A2T	DO229030	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.A24D	DO229045	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.A24D	DO228858	MALY	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.S15F	SIDM00007	Other Solid Cancers	GDSC	VNTSS	DEG_SPOP_SBC_1	0.7982
p.S15F	ACH-001550	Skin Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.7982
p.S15F	MCC13	skin	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.7982
p.W18R	SIDM00457	Plasma Cell Myeloma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	SIDM00970	Bladder Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	SIDM01377	Ovarian Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	ACH-000024	Myeloma	CCLE	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	ACH-000409	Ovarian Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	ACH-002235	Bladder Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	DSH1	urinary_tract	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.25
p.W18R	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.25
p.A25P	SIDM00217	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.0556
p.A25P	ACH-000999	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.0556
p.A25P	SNU-1040	large_intestine	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09619	Platelet-derived growth factor receptor beta	DEG_SPOP_SBC_1	1052:1056	VNTSS	SPOP	0.9079	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	369:373	VNTSS	SPOP	0.9386	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	145:149	VNTSS	SPOP	0.9158	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	221:225	VNTSS	SPOP	0.9787	More...
Q9H6R7	WD repeat and coiled-coil-containing protein	DEG_SPOP_SBC_1	482:486	VNTSS	SPOP	0.7588	More...
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_SPOP_SBC_1	154:158	VNTSS	SPOP	0.9935	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	456:460	VNTSS	SPOP	0.7805	More...
Q6Q759	Sperm-associated antigen 17	DEG_SPOP_SBC_1	11:15	VNTSS	SPOP	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNTSS

Degron related mutations and impact score

Drug responses associated with SPAG17 mutations

All proteins holding degron of VNTSS