DegronMD - Q8WWK9(CKAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K294Q	TCGA-06-5416	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation blocking ubiquitination signal	0.6111
p.N581S	TCGA-13-1499	OV	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.5958
p.K312N	TCGA-19-5956	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation substituting flanking lysine	0.2222
p.K312N	TCGA-Q1-A73O	CESC	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation substituting flanking lysine	0.2222
p.D561E	TCGA-AP-A1DK	UCEC	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.5647
p.T584M	TCGA-AX-A0J1	UCEC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.3056
p.T584M	TCGA-CA-6717	COAD	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.3056
p.P213H	TCGA-BH-A0C0	BRCA	TCGA	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.K301N	TCGA-BR-8680	STAD	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.5806
p.I309M	TCGA-BS-A0UV	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.E583K	TCGA-C5-A1MH	CESC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7022
p.L553R	TCGA-C8-A133	BRCA	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.2778
p.S304Y	TCGA-CA-6718	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.8231
p.K546Q	TCGA-CA-6718	COAD	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation substituting flanking lysine	0.1944
p.F242S	TCGA-CG-5721	STAD	TCGA	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.T584A	TCGA-CV-5966	HNSC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.3056
p.T246A	TCGA-D1-A160	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7139
p.M78I	TCGA-EE-A2MD	SKCM	TCGA	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.2778
p.K70T	TCGA-EO-A22X	UCEC	TCGA	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation blocking ubiquitination signal	0.5
p.P573A	TCGA-GC-A6I3	BLCA	TCGA	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.2222
p.V71A	TCGA-GF-A6C8	SKCM	TCGA	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.0833
p.M236I	TCGA-GN-A26C	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1389
p.K301R	TCGA-S3-AA11	BRCA	TCGA	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.6126
p.P572A	DO219025	BLCA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.1944
p.L552R	DO1926	BRCA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation blocking ubiquitination signal	0.6944
p.P79L	DO3500	BRCA	ICGC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.3056
p.K252R	DO51223	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.E582K	DO48982	CESC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7022
p.K545Q	DO7801	COAD	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.0556
p.S255Y	DO7801	COAD	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.N76I	DO8463	COAD	ICGC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.2222
p.T583M	DO8264	COAD	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7423
p.T583M	DO41199	UCEC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7423
p.K245Q	DO10880	GBM	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.6944
p.T583A	DO14950	HNSC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7139
p.R216W	DO14198	HNSC	ICGC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.H574R	DO228202	LICA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.25
p.R233L	DO228948	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R233L	DO228948	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.C561F	DO229031	LICA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.7108
p.S586I	DO229031	LICA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.25
p.H553Y	DO222868	MELA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.2778
p.N580S	DO31563	OV	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7069
p.G235W	DO46957	RECA	ICGC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.G235W	DO46957	RECA	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1111
p.S250N	DO219967	SARC	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.K252N	DO47769	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.D560E	DO42033	UCEC	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.6758
p.V593M	DO42384	UCEC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.0556
p.S75R	DO41584	UCEC	ICGC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation substituting flanking lysine	0.3056
p.G222D	DO43755	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.7198
p.A309P	DO43795	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.R310T	SIDM00313	Hodgkin's Lymphoma	GDSC	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310T	ACH-000702	Lymphoma	CCLE	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310T	L-1236	haematopoietic and lymphoid tissue	COSMIC	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.S90N	SIDM01090	Colorectal Carcinoma	GDSC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.S90N	ACH-000943	Colon/Colorectal Cancer	CCLE	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.S90N	RKO	large intestine	COSMIC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.L74R	SIDM01060	Melanoma	GDSC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.L74R	ACH-000882	Skin Cancer	CCLE	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.L74R	IGR-1	skin	COSMIC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1667
p.T574I	SIDM00039	Ovarian Carcinoma	GDSC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.25
p.L547R	SIDM00079	Ovarian Carcinoma	GDSC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.1111
p.L547R	ACH-000811	Ovarian Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.1111
p.L547R	SK-OV-3	ovary	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.1111
p.H554Y	SIDM01397	Melanoma	GDSC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.3056
p.H554Y	ACH-000765	Skin Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation rewiring degron network	0.3056
p.T211S	SIDM01491	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation blocking phosphorylation signal	0.5
p.T211S	ACH-000342	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation blocking phosphorylation signal	0.5
p.T579S	ACH-000779	Lung Cancer	CCLE	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.8227
p.P220H	ACH-001369	Ovarian Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.3056
p.L557S	ACH-002396	Bone Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.6556
p.L557S	Sarc9371	bone	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.6556
p.L73R	IGR-1	skin	COSMIC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation blocking ubiquitination signal	0.5833
p.V304A	EN	endometrium	COSMIC	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.6936
p.S546P	GP5d	large intestine	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation substituting flanking lysine	0.1944
p.R233W	22RV1	prostate	COSMIC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R233W	22RV1	prostate	COSMIC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.R581C	G-MEL	skin	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.8301
p.E584K	GP5d	large intestine	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation rewiring degron network	0.3056
p.R309T	L-1236	haematopoietic and lymphoid tissue	COSMIC	VKTSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.S89N	RKO	large intestine	COSMIC	DKENM	DEG_APCC_KENBOX_2	80:84	Mutation rewiring degron network	0.1944
p.R233Q	SNG-M	endometrium	COSMIC	VNTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R233Q	SNG-M	endometrium	COSMIC	VSTTS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0556
p.L546R	SK-OV-3	ovary	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation substituting flanking lysine	0.1944
p.R580Q	HT-115	large intestine	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	577:583	Mutation altering degron motif	0.7329
p.L556S	Sarc9371	bone	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	555:561	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CKAP2

UniProt ID: Q8WWK9

Entrez ID: 26586

Protein name: Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CKAP2 in