DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: DEG_SPOP_SBC_1

Location: 243:247

E3 ligase: SPOP

DEGRON score: 0.9283

ASA_SCORE: 90.04

COIL: 0.9332

CONS_SCORE: 0.3175

DSS_SCORE: 0.5712

HELIX: 0.037

FCONS_SCORE: 0.9848

RIG_SCORE: 0.7454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F242S	TCGA-CG-5721	STAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.3056
p.T246A	TCGA-D1-A160	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.7139
p.M236I	TCGA-GN-A26C	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1389
p.K252R	DO51223	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.S255Y	DO7801	COAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.K245Q	DO10880	GBM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6944
p.R233L	DO228948	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.G235W	DO46957	RECA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S250N	DO219967	SARC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.K252N	DO47769	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.R233W	22RV1	prostate	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R233Q	SNG-M	endometrium	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons