DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12353:12357

E3 ligase: SPOP

DEGRON score: 0.6523

ASA_SCORE: 73.48

COIL: 0.883

CONS_SCORE: 0

DSS_SCORE: 0.5097

HELIX: 0.0186

FCONS_SCORE: 0

RIG_SCORE: 0.6396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H12349N	TCGA-75-6211	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2222
p.H12349N	DO25173	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.V12344D	TCGA-BR-6452	STAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0833
p.V12344D	DO38404	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.R12367K	TCGA-EB-A3Y7	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R12367K	DO37499	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.L12366I	TCGA-EY-A1GI	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0833
p.L12366I	DO41211	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.S12352F	TCGA-F5-6814	READ	TCGA	VSTTS	DEG_SPOP_SBC_1	0.3056
p.S12352F	DO36556	READ	ICGC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.L12366R	DO50411	ESAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.L12366P	DO233749	GACA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.L12366F	DO233749	GACA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.T12355I	DO46791	PRAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7078
p.Q12350K	DO229216	THCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.R12367G	SIDM00781	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R12367G	SIDM00780	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R12367G	ACH-000967	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R12367G	ACH-001199	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.0556
p.R12367G	SNU-C2B	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.D12365H	SIDM00365	Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.D12365H	ACH-002196	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.D12365H	SBC-1	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S12357N	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.7069
p.S12357N	ACH-000511	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons