DegronMD

Uniprot ID: O95644

Source protein: Nuclear factor of activated T-cells, cytoplasmic 1

Source gene: NFATC1

Class: DEG_SPOP_SBC_1

Location: 502:506

E3 ligase: SPOP

DEGRON score: 0.7497

ASA_SCORE: 59.48

COIL: 0.7464

CONS_SCORE: 0.6106

DSS_SCORE: 0.3061

HELIX: 0.0214

FCONS_SCORE: 1.0033

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A516D	TCGA-DD-AADG	LIHC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0556
p.E495K	TCGA-EE-A29E	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1389
p.R515Q	TCGA-EY-A1GI	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1944
p.S506N	DO225346	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7069
p.Q493H	DO228974	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.V502L	DO229015	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6765
p.V494L	DO229009	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S512F	DO222662	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6111
p.S512F	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.6111
p.S512F	ACH-000012	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.6111
p.S512F	ACH-000029	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.6111
p.S512F	HCC-827	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.6111
p.G499W	DO37896	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.E508K	DO37831	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.T498I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.T498I	ACH-002256	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	0.2222
p.T498I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.S499F	HCC-827	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons