DegronMD - P47736(RAP1GAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A537V	TCGA-2W-A8YY	CESC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1111
p.A619T	TCGA-AA-3949	COAD	TCGA	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7139
p.A619T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7139
p.A528V	TCGA-CM-4746	COAD	TCGA	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation altering degron motif	0.6936
p.R631S	TCGA-D3-A2JG	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.0556
p.A620G	TCGA-HC-A6AN	PRAD	TCGA	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.754
p.R518G	DO222857	BTCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1667
p.V532I	DO223732	CESC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.25
p.R527C	DO7852	COAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation altering degron motif	0.8301
p.P536S	DO8642	COAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1389
p.P536S	DO51761	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1389
p.V609M	DO228123	EOPC	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.V609M	DO223007	ESCA	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.V609M	DO45368	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.I534T	DO233747	GACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1944
p.R528C	DO233898	GACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation altering degron motif	0.8301
p.P537Q	DO228948	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1111
p.T517K	DO229018	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1389
p.P536H	DO229034	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1389
p.E619G	DO25262	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7199
p.I534F	DO49085	LUSC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1944
p.G538R	DO221544	PACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.0833
p.S521L	DO232224	PBCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation substituting flanking lysine	0.3611
p.S521L	DO38723	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation substituting flanking lysine	0.3611
p.S521L	DO43907	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation substituting flanking lysine	0.3611
p.V626M	DO51407	PRAD	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.G530V	DO47278	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.3056
p.G530W	DO47623	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.3056
p.A531T	DO47757	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.2778
p.A531T	DO38202	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.2778
p.G618R	DO47717	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7568
p.G618R	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.7568
p.P516S	DO222335	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1111
p.A607V	DO229216	THCA	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.0556
p.G622C	DO223286	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.3056
p.G622D	DO43755	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.3056
p.E535D	DO41379	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1667
p.V613I	SIDM00945	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.V613I	CL-34	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.S523C	SIDM01752	Pancreatic Carcinoma	GDSC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.3056
p.S629T	ACH-000004	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.S629T	ACH-000005	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.S629T	HEL	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.S629P	ACH-000823	Esophageal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.S629P	ACH-001394	Breast Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.S629P	ACH-001688	Kidney Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1111
p.V528I	ACH-000895	Colon/Colorectal Cancer	CCLE	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation altering degron motif	0.5965
p.V528I	CL-34	large intestine	COSMIC	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation altering degron motif	0.5965
p.P516L	ACH-001570	Skin Cancer	CCLE	DSGHVS	DEG_SCF_TRCP1_1	524:529	Mutation rewiring degron network	0.1111
p.A623V	NCI-H1155	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2778
p.G613R	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.T611M	NCI-H1092	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667

Kaplan plot for RAP1GAP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAP1GAP

UniProt ID: P47736

Entrez ID: 5909

Protein name: Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAP1GAP in