DegronMD

Uniprot ID: P47736

Source protein: Rap1 GTPase-activating protein 1

Source gene: RAP1GAP

Class: DEG_SCF_TRCP1_1

Location: 524:529

E3 ligase: BTRC

DEGRON score: 0.9965

ASA_SCORE: 77.8167

COIL: 0.907

CONS_SCORE: 0.353

DSS_SCORE: 0.8754

HELIX: 0.0607

FCONS_SCORE: 1.0398

RIG_SCORE: 0.5198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A537V	TCGA-2W-A8YY	CESC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.1111
p.A528V	TCGA-CM-4746	COAD	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.6936
p.R518G	DO222857	BTCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1667
p.V532I	DO223732	CESC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.25
p.R527C	DO7852	COAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.8301
p.P536S	DO8642	COAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.P536S	DO51761	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.I534T	DO233747	GACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1944
p.R528C	DO233898	GACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.8301
p.P537Q	DO228948	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1111
p.T517K	DO229018	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.P536H	DO229034	LICA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.I534F	DO49085	LUSC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1944
p.G538R	DO221544	PACA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.0833
p.S521L	DO232224	PBCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3611
p.S521L	DO38723	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3611
p.S521L	DO43907	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3611
p.G530V	DO47278	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.G530W	DO47623	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.A531T	DO47757	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.2778
p.A531T	DO38202	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.2778
p.P516S	DO222335	STAD	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1111
p.E535D	DO41379	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1667
p.S523C	SIDM01752	Pancreatic Carcinoma	GDSC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.V528I	ACH-000895	Colon/Colorectal Cancer	CCLE	DSGHVS	DEG_SCF_TRCP1_1	0.5965
p.V528I	CL-34	large_intestine	COSMIC	DSGHVS	DEG_SCF_TRCP1_1	0.5965
p.P516L	ACH-001570	Skin Cancer	CCLE	DSGHVS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47736	Rap1 GTPase-activating protein 1	DEG_SCF_TRCP1_1	524:529	DSGHVS	BTRC	0.9965	More...
Q10571	Transcriptional activator MN1	DEG_SCF_TRCP1_1	949:954	DSGHVS	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons