DegronMD

Uniprot ID: Q10571

Source protein: Transcriptional activator MN1

Source gene: MN1

Class: DEG_SCF_TRCP1_1

Location: 949:954

E3 ligase: BTRC

DEGRON score: 0.9985

ASA_SCORE: 82.2833

COIL: 0.9347

CONS_SCORE: 0.9936

DSS_SCORE: 0.6723

HELIX: 0.021

FCONS_SCORE: 1.2831

RIG_SCORE: 0.6013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P955H	TCGA-AP-A1DH	UCEC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.P955H	DO43995	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.G939D	TCGA-DU-6407	LGG	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.0556
p.G939D	DO22295	LGG	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.0556
p.G942R	TCGA-EE-A29N	SKCM	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.G942R	DO38001	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.1389
p.R945C	TCGA-FA-A4BB	DLBC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.2222
p.R945C	DO219885	DLBC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.2222
p.D949N	TCGA-JW-A5VL	CESC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	0.6932
p.D949N	DO49976	CESC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.6932
p.R948K	DO222632	MELA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.P955S	DO222875	MELA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.3056
p.T957I	DO229453	SKCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47736	Rap1 GTPase-activating protein 1	DEG_SCF_TRCP1_1	524:529	DSGHVS	BTRC	0.9965	More...
Q10571	Transcriptional activator MN1	DEG_SCF_TRCP1_1	949:954	DSGHVS	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons