DegronMD - Q10571(MN1)

FUNCTION: Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}.

GO - Biological processes (BP): intramembranous ossification [GO:0001957]; negative regulation of osteoblast proliferation [GO:0033689]; positive regulation of vitamin D receptor signaling pathway [GO:0070564]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of transcription, DNA-templated [GO:0006355]

GO - Molecular function (MF):

GO - Cellular component (CC): nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DKYSAAP	CBL_PTK	CBL	Transcriptional activator MN1	960:966	More..
LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	VHL	Transcriptional activator MN1	663:676	More..
VRTPTSS	DEG_SCF_FBW7_1	FBXW7	Transcriptional activator MN1	1135:1141	More..
PGTPGLE	DEG_SCF_FBW7_2	FBXW7	Transcriptional activator MN1	1127:1133	More..
DSGHVS	DEG_SCF_TRCP1_1	BTRC	Transcriptional activator MN1	949:954	More..
VSSSS	DEG_SPOP_SBC_1	SPOP	Transcriptional activator MN1	1059:1063	More..
PTSSS	DEG_SPOP_SBC_1	SPOP	Transcriptional activator MN1	1138:1142	More..
MHPYSE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Transcriptional activator MN1	419:424	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E424G	TCGA-FI-A2D6	UCEC	TCGA	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.7199
p.E424G	DO43867	UCEC	ICGC	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.7199
p.T957I	DO229453	SKCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation blocking phosphorylation signal	0.6944
p.T957I	DO229453	SKCA	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation blocking phosphorylation signal	0.6944
p.D949N	TCGA-JW-A5VL	CESC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation altering degron motif	0.6932
p.D949N	DO49976	CESC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation altering degron motif	0.6932
p.P966S	TCGA-FS-A1ZA	SKCM	TCGA	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.6752
p.P966S	DO37551	SKCM	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.6752
p.P1138S	DO222363	MELA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation altering degron motif	0.6752
p.P1138S	DO222363	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.6752
p.P666H	SIDM00282	Colorectal Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6583
p.S672L	DO234459	ESAD	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6556
p.S672L	SIDM00652	Small Cell Lung Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6556
p.P668L	SIDM01155	Glioma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6471
p.R1136S	DO23226	LINC	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation altering degron motif	0.6316
p.G1131D	ACH-000342	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation altering degron motif	0.6087
p.G1131D	ACH-000491	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation altering degron motif	0.6087
p.K961N	TCGA-55-8507	LUAD	TCGA	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.5806
p.K961N	DO45412	LUAD	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.5806
p.D1064G	TCGA-AD-6895	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

MN1

UniProt ID: Q10571

Entrez ID: 4330

Protein name: Transcriptional activator MN1 (Probable tumor suppressor protein MN1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MN1 in