DegronMD - Q10571(MN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1073N	TCGA-06-5416	GBM	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0556
p.S1073N	DO10880	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0556
p.A1054T	TCGA-06-5416	GBM	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1944
p.A1054T	DO10880	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1944
p.K961N	TCGA-55-8507	LUAD	TCGA	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.5806
p.K961N	DO45412	LUAD	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.5806
p.P1152R	TCGA-59-A5PD	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.P1152R	DO50085	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.S1050G	TCGA-A5-A0G1	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0833
p.S1050G	DO42472	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0833
p.D1064G	TCGA-AD-6895	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056
p.D1064G	DO8938	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056
p.P955H	TCGA-AP-A1DH	UCEC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.3056
p.P955H	TCGA-AP-A1DH	UCEC	TCGA	DKYSAAP	CBL_PTK	960:966	Mutation rewiring degron network	0.1944
p.P955H	DO43995	UCEC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.3056
p.P955H	DO43995	UCEC	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation rewiring degron network	0.1944
p.V1070I	TCGA-B5-A11H	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1389
p.V1070I	DO42825	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1389
p.G939D	TCGA-DU-6407	LGG	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.0556
p.G939D	DO22295	LGG	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.0556
p.P1152L	TCGA-EB-A4XL	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.P1152L	DO47401	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.G942R	TCGA-EE-A29N	SKCM	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.1389
p.G942R	DO38001	SKCM	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.1389
p.K1071T	TCGA-EO-A3B0	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation substituting flanking lysine	0.2222
p.K1071T	DO219773	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation substituting flanking lysine	0.2222
p.R945C	TCGA-FA-A4BB	DLBC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.2222
p.R945C	DO219885	DLBC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.2222
p.E424G	TCGA-FI-A2D6	UCEC	TCGA	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.7199
p.E424G	DO43867	UCEC	ICGC	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation altering degron motif	0.7199
p.E1058K	TCGA-FR-A726	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056
p.E1058K	DO222546	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056
p.E1058K	DO48665	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.3056
p.P966S	TCGA-FS-A1ZA	SKCM	TCGA	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.6752
p.P966S	DO37551	SKCM	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation altering degron motif	0.6752
p.S1050C	TCGA-FV-A4ZQ	LIHC	TCGA	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0833
p.S1050C	DO44877	LIHC	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0833
p.D949N	TCGA-JW-A5VL	CESC	TCGA	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation altering degron motif	0.6932
p.D949N	DO49976	CESC	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation altering degron motif	0.6932
p.I1150V	DO222427	BTCA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.0833
p.I1150V	DO222427	BTCA	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1111
p.S672L	DO234459	ESAD	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6556
p.S672L	SIDM00652	Small Cell Lung Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6556
p.A1144T	DO223068	ESCA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.25
p.A1144T	DO223068	ESCA	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2778
p.A971T	DO233288	GACA	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation rewiring degron network	0.1944
p.P976T	DO233652	GACA	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation rewiring degron network	0.0556
p.Q1134H	DO233748	GACA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.3056
p.Q1134H	DO233748	GACA	ICGC	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation rewiring degron network	0.3056
p.Q1134H	DO233748	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.2222
p.S662I	DO233805	GACA	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation rewiring degron network	0.3056
p.P434L	DO233807	GACA	ICGC	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.S1050R	DO229018	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.0833
p.Q1067K	DO229037	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.2222
p.R1136S	DO23226	LINC	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation altering degron motif	0.6316
p.P1138S	DO222363	MELA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation altering degron motif	0.6752
p.P1138S	DO222363	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation altering degron motif	0.6752
p.R948K	DO222632	MELA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.3056
p.P955S	DO222875	MELA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation rewiring degron network	0.3056
p.P955S	DO222875	MELA	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation rewiring degron network	0.1944
p.T957I	DO229453	SKCA	ICGC	DSGHVS	DEG_SCF_TRCP1_1	949:954	Mutation blocking phosphorylation signal	0.6944
p.T957I	DO229453	SKCA	ICGC	DKYSAAP	CBL_PTK	960:966	Mutation blocking phosphorylation signal	0.6944
p.M686T	DO229268	THCA	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation rewiring degron network	0.0556
p.P1145L	SIDM00238	Ovarian Carcinoma	GDSC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.2222
p.P1145L	SIDM00238	Ovarian Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.P1145L	ACH-000947	Ovarian Cancer	CCLE	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.2222
p.P1145L	ACH-000947	Ovarian Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.P666H	SIDM00282	Colorectal Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6583
p.G1143R	SIDM00280	Gastric Carcinoma	GDSC	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.2778
p.G1143R	SIDM00280	Gastric Carcinoma	GDSC	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation rewiring degron network	0.0556
p.G1143R	SIDM00280	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.3056
p.G1143R	ACH-000560	Gastric Cancer	CCLE	VRTPTSS	DEG_SCF_FBW7_1	1135:1141	Mutation rewiring degron network	0.2778
p.G1143R	ACH-000560	Gastric Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation rewiring degron network	0.0556
p.G1143R	ACH-000560	Gastric Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.3056
p.T1051M	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.T1051M	ACH-000937	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.T1051M	PF-382	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	1059:1063	Mutation rewiring degron network	0.1111
p.P668L	SIDM01155	Glioma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	663:676	Mutation altering degron motif	0.6471
p.P434Q	SIDM00901	Endometrial Carcinoma	GDSC	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.P434Q	ACH-000940	Endometrial/Uterine Cancer	CCLE	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.P434Q	AN3-CA	endometrium	COSMIC	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.0556
p.G1131D	ACH-000342	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation altering degron motif	0.6087
p.G1131D	ACH-000491	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation altering degron motif	0.6087
p.E415G	ACH-000950	Colon/Colorectal Cancer	CCLE	MHPYSE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.2222
p.G1121S	ACH-000997	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	1127:1133	Mutation rewiring degron network	0.1667
p.P1152S	ACH-002005	Skin Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MN1

UniProt ID: Q10571

Entrez ID: 4330

Protein name: Transcriptional activator MN1 (Probable tumor suppressor protein MN1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MN1 in