DegronMD

Uniprot ID: Q10571

Source protein: Transcriptional activator MN1

Source gene: MN1

Class: DEG_SCF_FBW7_2

Location: 1127:1133

E3 ligase: FBXW7

DEGRON score: 0.9858

ASA_SCORE: 84.7714

COIL: 0.9407

CONS_SCORE: 0.897

DSS_SCORE: 0.8239

HELIX: 0.0444

FCONS_SCORE: 1.2482

RIG_SCORE: 0.5538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1134H	DO233748	GACA	ICGC	PGTPGLE	DEG_SCF_FBW7_2	0.3056
p.G1143R	SIDM00280	Gastric Carcinoma	GDSC	PGTPGLE	DEG_SCF_FBW7_2	0.0556
p.G1143R	ACH-000560	Gastric Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	0.0556
p.G1131D	ACH-000342	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	0.6087
p.G1131D	ACH-000491	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	0.6087
p.G1121S	ACH-000997	Colon/Colorectal Cancer	CCLE	PGTPGLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10571	Transcriptional activator MN1	DEG_SCF_FBW7_2	1127:1133	PGTPGLE	FBXW7	0.9858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons