DegronMD

Uniprot ID: Q10571

Source protein: Transcriptional activator MN1

Source gene: MN1

Class: DEG_SCF_FBW7_1

Location: 1135:1141

E3 ligase: FBXW7

DEGRON score: 0.9258

ASA_SCORE: 91.3857

COIL: 0.9317

CONS_SCORE: 0.896

DSS_SCORE: 0.8778

HELIX: 0.0239

FCONS_SCORE: 1.1587

RIG_SCORE: 0.5957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1150V	DO222427	BTCA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	0.0833
p.A1144T	DO223068	ESCA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	0.25
p.Q1134H	DO233748	GACA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	0.3056
p.R1136S	DO23226	LINC	ICGC	VRTPTSS	DEG_SCF_FBW7_1	0.6316
p.P1138S	DO222363	MELA	ICGC	VRTPTSS	DEG_SCF_FBW7_1	0.6752
p.P1145L	SIDM00238	Ovarian Carcinoma	GDSC	VRTPTSS	DEG_SCF_FBW7_1	0.2222
p.P1145L	ACH-000947	Ovarian Cancer	CCLE	VRTPTSS	DEG_SCF_FBW7_1	0.2222
p.G1143R	SIDM00280	Gastric Carcinoma	GDSC	VRTPTSS	DEG_SCF_FBW7_1	0.2778
p.G1143R	ACH-000560	Gastric Cancer	CCLE	VRTPTSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10571	Transcriptional activator MN1	DEG_SCF_FBW7_1	1135:1141	VRTPTSS	FBXW7	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons