DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DKYSAAP
Uniprot ID:
Q10571
Source protein:
Transcriptional activator MN1
Source gene:
MN1
Class:
CBL_PTK
Location:
960:966
E3 ligase:
CBL
DEGRON score:
0.9387
ASA_SCORE:
86.8143
COIL:
0.8473
CONS_SCORE:
0.4299
DSS_SCORE:
0.6061
HELIX:
0.121
FCONS_SCORE:
0.5173
RIG_SCORE:
0.7097
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K961N
TCGA-55-8507
LUAD
TCGA
DKYSAAP
CBL_PTK
0.5806
p.K961N
DO45412
LUAD
ICGC
DKYSAAP
CBL_PTK
0.5806
p.P955H
TCGA-AP-A1DH
UCEC
TCGA
DKYSAAP
CBL_PTK
0.1944
p.P955H
DO43995
UCEC
ICGC
DKYSAAP
CBL_PTK
0.1944
p.P966S
TCGA-FS-A1ZA
SKCM
TCGA
DKYSAAP
CBL_PTK
0.6752
p.P966S
DO37551
SKCM
ICGC
DKYSAAP
CBL_PTK
0.6752
p.A971T
DO233288
GACA
ICGC
DKYSAAP
CBL_PTK
0.1944
p.P976T
DO233652
GACA
ICGC
DKYSAAP
CBL_PTK
0.0556
p.P955S
DO222875
MELA
ICGC
DKYSAAP
CBL_PTK
0.1944
p.T957I
DO229453
SKCA
ICGC
DKYSAAP
CBL_PTK
0.6944
Drug responses associated with MN1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKYSAAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q10571
Transcriptional activator MN1
CBL_PTK
960:966
DKYSAAP
CBL
0.9387
More...
