DegronMD

Uniprot ID: Q10571

Source protein: Transcriptional activator MN1

Source gene: MN1

Class: DEG_ODPH_VHL_1

Location: 663:676

E3 ligase: VHL

DEGRON score: 0.8304

ASA_SCORE: 82.3786

COIL: 0.9594

CONS_SCORE: 0.5774

DSS_SCORE: 0.7299

HELIX: 0.0183

FCONS_SCORE: 0.9018

RIG_SCORE: 0.5361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S672L	DO234459	ESAD	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.6556
p.S672L	SIDM00652	Small Cell Lung Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.6556
p.S662I	DO233805	GACA	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.3056
p.M686T	DO229268	THCA	ICGC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.0556
p.P666H	SIDM00282	Colorectal Carcinoma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.6583
p.P668L	SIDM01155	Glioma	GDSC	LAPPPPPGGSGVLF	DEG_ODPH_VHL_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10571	Transcriptional activator MN1	DEG_ODPH_VHL_1	663:676	LAPPPPPGGSGVLF	VHL	0.8304	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons