DegronMD

Uniprot ID: Q10571

Source protein: Transcriptional activator MN1

Source gene: MN1

Class: LIG_APCC_ABBA_1

Location: 419:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.941

ASA_SCORE: 98.3167

COIL: 0.9337

CONS_SCORE: 0.787

DSS_SCORE: 0.5806

HELIX: 0.0325

FCONS_SCORE: 0.9466

RIG_SCORE: 0.6208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E424G	TCGA-FI-A2D6	UCEC	TCGA	MHPYSE	LIG_APCC_ABBA_1	0.7199
p.E424G	DO43867	UCEC	ICGC	MHPYSE	LIG_APCC_ABBA_1	0.7199
p.P434L	DO233807	GACA	ICGC	MHPYSE	LIG_APCC_ABBA_1	0.0556
p.P434Q	SIDM00901	Endometrial Carcinoma	GDSC	MHPYSE	LIG_APCC_ABBA_1	0.0556
p.P434Q	ACH-000940	Endometrial/Uterine Cancer	CCLE	MHPYSE	LIG_APCC_ABBA_1	0.0556
p.P434Q	AN3-CA	endometrium	COSMIC	MHPYSE	LIG_APCC_ABBA_1	0.0556
p.E415G	ACH-000950	Colon/Colorectal Cancer	CCLE	MHPYSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10571	Transcriptional activator MN1	LIG_APCC_ABBA_1	419:424	MHPYSE	APC,CDC20,FZR1	0.941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons