DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: DEG_SPOP_SBC_1

Location: 300:304

E3 ligase: SPOP

DEGRON score: 0.9861

ASA_SCORE: 92.12

COIL: 0.8802

CONS_SCORE: 0.3266

DSS_SCORE: 0.4374

HELIX: 0.0738

FCONS_SCORE: 1.1331

RIG_SCORE: 0.7001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K294Q	TCGA-06-5416	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	0.6111
p.K312N	TCGA-19-5956	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.K312N	TCGA-Q1-A73O	CESC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.K301N	TCGA-BR-8680	STAD	TCGA	VKTSS	DEG_SPOP_SBC_1	0.5806
p.I309M	TCGA-BS-A0UV	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1944
p.S304Y	TCGA-CA-6718	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	0.8231
p.K301R	TCGA-S3-AA11	BRCA	TCGA	VKTSS	DEG_SPOP_SBC_1	0.6126
p.A309P	DO43795	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1944
p.R310T	SIDM00313	Hodgkin's Lymphoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.1667
p.R310T	ACH-000702	Lymphoma	CCLE	VKTSS	DEG_SPOP_SBC_1	0.1667
p.R310T	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.1667
p.V304A	EN	endometrium	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.6936
p.R309T	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons