DegronMD - Q8WUA4(GTF3C2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P761Q	TCGA-09-2044	OV	TCGA	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.7035
p.P761Q	TCGA-A5-A0G2	UCEC	TCGA	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.7035
p.P761Q	DO28923	OV	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.7035
p.P761Q	DO41235	UCEC	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.7035
p.N32D	TCGA-37-A5EN	LUSC	TCGA	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2222
p.N32D	DO223720	LUSC	ICGC	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2222
p.P279S	TCGA-3N-A9WC	SKCM	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation altering degron motif	0.6752
p.P279S	DO51234	SKCM	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation altering degron motif	0.6752
p.C291R	TCGA-A5-A0G9	UCEC	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0833
p.C291R	DO42304	UCEC	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0833
p.R750Q	TCGA-AA-3984	COAD	TCGA	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.R750Q	DO9002	COAD	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.R750Q	DO233203	GACA	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.R750Q	DO233731	GACA	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.P487S	TCGA-D9-A1JW	SKCM	TCGA	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1389
p.P487S	DO37786	SKCM	ICGC	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1389
p.D35N	TCGA-DK-A1A3	BLCA	TCGA	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.D35N	DO558	BLCA	ICGC	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.S266T	TCGA-EI-7002	READ	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0833
p.S266T	DO36598	READ	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0833
p.H290R	TCGA-HU-A4H3	STAD	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1111
p.H290R	DO47903	STAD	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1111
p.S39C	TCGA-IR-A3LA	CESC	TCGA	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.8652
p.S39C	DO44377	CESC	ICGC	VKTSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.8652
p.P766T	TCGA-L5-A4OI	ESCA	TCGA	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.2778
p.P753S	DO229018	LICA	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1667
p.R276Q	DO220878	MELA	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation altering degron motif	0.6218
p.P761S	DO222749	MELA	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.6752
p.P761L	DO222908	MELA	ICGC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.6471
p.P279A	DO51137	PRAD	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation altering degron motif	0.7503
p.A774V	SIDM00216	Colorectal Carcinoma	GDSC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0556
p.A774V	ACH-000989	Colon/Colorectal Cancer	CCLE	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0556
p.A774V	SNU-175	large intestine	COSMIC	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0556
p.P272L	SIDM00545	Melanoma	GDSC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.25
p.P272L	ACH-000987	Skin Cancer	CCLE	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.25
p.P272L	Mewo	skin	COSMIC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.25
p.S268F	SIDM00007	Other Solid Cancers	GDSC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation blocking phosphorylation signal	0.5833
p.S268F	ACH-001550	Skin Cancer	CCLE	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation blocking phosphorylation signal	0.5833
p.S268F	MCC13	skin	COSMIC	PRSTPRGS	DEG_SCF_FBW7_1	275:282	Mutation blocking phosphorylation signal	0.5833
p.R488Q	SIDM00477	Esophageal Carcinoma	GDSC	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1667
p.R488Q	ACH-000383	Esophageal Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1667
p.K507E	SIDM00383	Gastric Carcinoma	GDSC	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation substituting flanking lysine	0.3056
p.K507E	ACH-002198	Gastric Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation substituting flanking lysine	0.3056
p.K507E	SCH	stomach	COSMIC	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation substituting flanking lysine	0.3056
p.P491L	ACH-000246	Kidney Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.25
p.S772F	ACH-001366	Neuroblastoma	CCLE	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1111
p.T486S	ACH-001841	Bile Duct Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	494:502	Mutation blocking phosphorylation signal	0.5556
p.Q763E	ACH-001864	Bile Duct Cancer	CCLE	LIPYQD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.5633

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTF3C2

UniProt ID: Q8WUA4

Entrez ID: 2976

Protein name: General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTF3C2 in