DegronMD

Uniprot ID: Q8WUA4

Source protein: General transcription factor 3C polypeptide 2

Source gene: GTF3C2

Class: DEG_APCC_DBOX_1

Location: 494:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7457

ASA_SCORE: 11.2556

COIL: 0.1463

CONS_SCORE: 0.7013

DSS_SCORE: 0.0799

HELIX: 0.0111

FCONS_SCORE: 1.4302

RIG_SCORE: 0.8397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P487S	TCGA-D9-A1JW	SKCM	TCGA	PRLGLLALA	DEG_APCC_DBOX_1	0.1389
p.P487S	DO37786	SKCM	ICGC	PRLGLLALA	DEG_APCC_DBOX_1	0.1389
p.R488Q	SIDM00477	Esophageal Carcinoma	GDSC	PRLGLLALA	DEG_APCC_DBOX_1	0.1667
p.R488Q	ACH-000383	Esophageal Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	0.1667
p.K507E	SIDM00383	Gastric Carcinoma	GDSC	PRLGLLALA	DEG_APCC_DBOX_1	0.3056
p.K507E	ACH-002198	Gastric Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	0.3056
p.K507E	SCH	stomach	COSMIC	PRLGLLALA	DEG_APCC_DBOX_1	0.3056
p.P491L	ACH-000246	Kidney Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	0.25
p.T486S	ACH-001841	Bile Duct Cancer	CCLE	PRLGLLALA	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_APCC_DBOX_1	494:502	PRLGLLALA	APC,CDC20,FZR1	0.7457	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons