DegronMD

Uniprot ID: Q8WUA4

Source protein: General transcription factor 3C polypeptide 2

Source gene: GTF3C2

Class: DEG_SCF_FBW7_1

Location: 275:282

E3 ligase: FBXW7

DEGRON score: 0.9562

ASA_SCORE: 92.5375

COIL: 0.9548

CONS_SCORE: 0.4015

DSS_SCORE: 0.7897

HELIX: 0.0211

FCONS_SCORE: 1.0967

RIG_SCORE: 0.5259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P279S	TCGA-3N-A9WC	SKCM	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	0.6752
p.P279S	DO51234	SKCM	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.6752
p.C291R	TCGA-A5-A0G9	UCEC	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	0.0833
p.C291R	DO42304	UCEC	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.0833
p.S266T	TCGA-EI-7002	READ	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	0.0833
p.S266T	DO36598	READ	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.0833
p.H290R	TCGA-HU-A4H3	STAD	TCGA	PRSTPRGS	DEG_SCF_FBW7_1	0.1111
p.H290R	DO47903	STAD	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.1111
p.R276Q	DO220878	MELA	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.6218
p.P279A	DO51137	PRAD	ICGC	PRSTPRGS	DEG_SCF_FBW7_1	0.7503
p.P272L	SIDM00545	Melanoma	GDSC	PRSTPRGS	DEG_SCF_FBW7_1	0.25
p.P272L	ACH-000987	Skin Cancer	CCLE	PRSTPRGS	DEG_SCF_FBW7_1	0.25
p.P272L	Mewo	skin	COSMIC	PRSTPRGS	DEG_SCF_FBW7_1	0.25
p.S268F	SIDM00007	Other Solid Cancers	GDSC	PRSTPRGS	DEG_SCF_FBW7_1	0.5833
p.S268F	ACH-001550	Skin Cancer	CCLE	PRSTPRGS	DEG_SCF_FBW7_1	0.5833
p.S268F	MCC13	skin	COSMIC	PRSTPRGS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SCF_FBW7_1	275:282	PRSTPRGS	FBXW7	0.9562	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons