DegronMD

Uniprot ID: Q8WUA4

Source protein: General transcription factor 3C polypeptide 2

Source gene: GTF3C2

Class: DEG_SPOP_SBC_1

Location: 36:40

E3 ligase: SPOP

DEGRON score: 0.7835

ASA_SCORE: 92.96

COIL: 0.8786

CONS_SCORE: 0.3578

DSS_SCORE: 0.5424

HELIX: 0.0968

FCONS_SCORE: 0.9472

RIG_SCORE: 0.7279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N32D	TCGA-37-A5EN	LUSC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.N32D	DO223720	LUSC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.D35N	TCGA-DK-A1A3	BLCA	TCGA	VKTSS	DEG_SPOP_SBC_1	0.3056
p.D35N	DO558	BLCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.3056
p.S39C	TCGA-IR-A3LA	CESC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.8652
p.S39C	DO44377	CESC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.8652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons