DegronMD

Uniprot ID: Q9UK28

Source protein: Transmembrane protein 59-like

Source gene: TMEM59L

Class: DEG_SPOP_SBC_1

Location: 237:241

E3 ligase: SPOP

DEGRON score: 0.8378

ASA_SCORE: 97.28

COIL: 0.8306

CONS_SCORE: 0.4463

DSS_SCORE: 0.4647

HELIX: 0.1076

FCONS_SCORE: 1.2976

RIG_SCORE: 0.7222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S241N	TCGA-06-5416	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	0.7069
p.S241N	DO10880	GBM	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7069
p.V230A	TCGA-AP-A054	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1389
p.V230A	DO42256	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1389
p.S247F	TCGA-C8-A1HM	BRCA	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1667
p.S247F	DO3904	BRCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1667
p.V245A	TCGA-EY-A1GD	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.V245A	DO42129	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.S240N	TCGA-EY-A1GK	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.7069
p.S240N	TCGA-G4-6320	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	0.7069
p.S240N	DO8159	COAD	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7069
p.S240N	DO42985	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7069
p.E248Q	DO48429	BLCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1389
p.A243V	DO229010	COCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.A243V	SIDM00544	Neuroblastoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.A243V	SIDM00054	Pancreatic Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.A243V	SIDM01335	Kidney Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.A243V	SIDM01729	Endometrial Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.E249K	ACH-000194	Non-Cancerous	CCLE	VKTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons