DegronMD - Q9UK28(TMEM59L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V221L	TCGA-05-5425	LUAD	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation altering degron motif	0.5654
p.V221L	DO26270	LUAD	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation altering degron motif	0.5654
p.S241N	TCGA-06-5416	GBM	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.S241N	DO10880	GBM	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.T208I	TCGA-21-1079	LUSC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.0833
p.T208I	DO26846	LUSC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.0833
p.R210Q	TCGA-85-A4QQ	LUSC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.R210Q	DO223114	ESCA	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.R210Q	DO45427	LUSC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.R210Q	SIDM00193	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.R210Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.R210Q	SNU-81	large intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1389
p.V230A	TCGA-AP-A054	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.V230A	TCGA-AP-A054	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1111
p.V230A	DO42256	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.V230A	DO42256	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1111
p.V221M	TCGA-BG-A221	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation altering degron motif	0.6097
p.V221M	DO42384	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation altering degron motif	0.6097
p.G225A	TCGA-BG-A222	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.G225A	DO42977	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.S247F	TCGA-C8-A1HM	BRCA	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.S247F	DO3904	BRCA	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.V207M	TCGA-D3-A8GC	SKCM	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.0556
p.V207M	DO50281	SKCM	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.0556
p.H213Y	TCGA-EO-A3AU	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2222
p.H213Y	DO43827	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2222
p.V245A	TCGA-EY-A1GD	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.V245A	DO42129	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.S240N	TCGA-EY-A1GK	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.S240N	TCGA-G4-6320	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.S240N	DO8159	COAD	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.S240N	DO42985	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7069
p.E248Q	DO48429	BLCA	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.A243V	DO229010	COCA	ICGC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.A243V	SIDM00544	Neuroblastoma	GDSC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.A243V	SIDM00054	Pancreatic Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.A243V	SIDM01335	Kidney Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.A243V	SIDM01729	Endometrial Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.S212P	DO233885	GACA	ICGC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.1944
p.V224I	SIDM00282	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2778
p.V224I	ACH-000998	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2778
p.V224I	CW-2	large intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2778
p.G225C	SIDM00537	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.G225C	ACH-000982	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.G225C	ACH-001345	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.G225C	GP5d	large intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.25
p.P226L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2222
p.P226L	ACH-000851	Lung Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	217:222	Mutation rewiring degron network	0.2222
p.E249K	ACH-000194	Non-Cancerous	CCLE	VKTSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM59L

UniProt ID: Q9UK28

Entrez ID: 25789

Protein name: Transmembrane protein 59-like (Brain-specific membrane-anchored protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM59L in