DegronMD

Uniprot ID: Q9UK28

Source protein: Transmembrane protein 59-like

Source gene: TMEM59L

Class: LIG_APCC_ABBA_1

Location: 217:222

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9757

ASA_SCORE: 76.8333

COIL: 0.764

CONS_SCORE: 0.3562

DSS_SCORE: 0.4575

HELIX: 0.1553

FCONS_SCORE: 1.0747

RIG_SCORE: 0.783

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V221L	TCGA-05-5425	LUAD	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.5654
p.V221L	DO26270	LUAD	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.5654
p.T208I	TCGA-21-1079	LUSC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.0833
p.T208I	DO26846	LUSC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.0833
p.R210Q	TCGA-85-A4QQ	LUSC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.R210Q	DO223114	ESCA	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.R210Q	DO45427	LUSC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.R210Q	SIDM00193	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.R210Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.R210Q	SNU-81	large_intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	0.1389
p.V230A	TCGA-AP-A054	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.1111
p.V230A	DO42256	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.1111
p.V221M	TCGA-BG-A221	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.6097
p.V221M	DO42384	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.6097
p.G225A	TCGA-BG-A222	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.25
p.G225A	DO42977	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.25
p.V207M	TCGA-D3-A8GC	SKCM	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.0556
p.V207M	DO50281	SKCM	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.0556
p.H213Y	TCGA-EO-A3AU	UCEC	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.H213Y	DO43827	UCEC	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.S212P	DO233885	GACA	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.1944
p.V224I	SIDM00282	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	0.2778
p.V224I	ACH-000998	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.2778
p.V224I	CW-2	large_intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	0.2778
p.G225C	SIDM00537	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	0.25
p.G225C	ACH-000982	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.25
p.G225C	ACH-001345	Colon/Colorectal Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.25
p.G225C	GP5d	large_intestine	COSMIC	LEVHVD	LIG_APCC_ABBA_1	0.25
p.P226L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.P226L	ACH-000851	Lung Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEVHVD

Degron related mutations and impact score

Drug responses associated with TMEM59L mutations

All proteins holding degron of LEVHVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60884	DnaJ homolog subfamily A member 2	LIG_APCC_ABBA_1	217:222	LEVHVD	APC,CDC20,FZR1	0.9391	More...
Q9UK28	Transmembrane protein 59-like	LIG_APCC_ABBA_1	217:222	LEVHVD	APC,CDC20,FZR1	0.9757	More...