DegronMD

Uniprot ID: O60884

Source protein: DnaJ homolog subfamily A member 2

Source gene: DNAJA2

Class: LIG_APCC_ABBA_1

Location: 217:222

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9391

ASA_SCORE: 52

COIL: 0.2575

CONS_SCORE: 0.6347

DSS_SCORE: 0.3285

HELIX: 0.0012

FCONS_SCORE: 1.2092

RIG_SCORE: 0.8637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R230I	TCGA-AG-A002	READ	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.1111
p.V219D	TCGA-BR-6452	STAD	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.7785
p.V219D	DO38404	STAD	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.7785
p.K209Q	TCGA-IN-A6RL	STAD	TCGA	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.K209Q	DO51738	STAD	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.D222E	DO229045	LICA	ICGC	LEVHVD	LIG_APCC_ABBA_1	0.5647
p.K209R	SIDM01951	Colorectal Carcinoma	GDSC	LEVHVD	LIG_APCC_ABBA_1	0.2222
p.K208N	ACH-000954	Endometrial/Uterine Cancer	CCLE	LEVHVD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60884	DnaJ homolog subfamily A member 2	LIG_APCC_ABBA_1	217:222	LEVHVD	APC,CDC20,FZR1	0.9391	More...
Q9UK28	Transmembrane protein 59-like	LIG_APCC_ABBA_1	217:222	LEVHVD	APC,CDC20,FZR1	0.9757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons