DegronMD

Uniprot ID: Q5XKE5

Source protein: Keratin, type II cytoskeletal 79

Source gene: KRT79

Class: DEG_SPOP_SBC_1

Location: 528:532

E3 ligase: SPOP

DEGRON score: 0.6487

ASA_SCORE: 94

COIL: 0.8858

CONS_SCORE: 0.7728

DSS_SCORE: 0.7085

HELIX: 0.0686

FCONS_SCORE: 0.9929

RIG_SCORE: 0.7762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T530M	TCGA-78-8660	LUAD	TCGA	VKTSS	DEG_SPOP_SBC_1	0.7423
p.T530M	DO222389	BTCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7423
p.T530M	DO45321	LUAD	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7423
p.L522M	TCGA-A4-7583	KIRP	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1667
p.L522M	DO20870	KIRP	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1667
p.K524N	DO42673	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.3333
p.T527M	SIDM00633	Breast Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.75
p.T527M	SIDM00483	Esophageal Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.75
p.T527M	SIDM01133	Other Solid Cancers	GDSC	VKTSS	DEG_SPOP_SBC_1	0.75
p.T527M	SIDM00785	Acute Myeloid Leukemia	GDSC	VKTSS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons