DegronMD

Uniprot ID: Q8WUA4

Source protein: General transcription factor 3C polypeptide 2

Source gene: GTF3C2

Class: LIG_APCC_ABBA_1

Location: 759:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8786

ASA_SCORE: 75.9667

COIL: 0.4632

CONS_SCORE: 0.3763

DSS_SCORE: 0.5151

HELIX: 0.0117

FCONS_SCORE: 0.8908

RIG_SCORE: 0.7095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P761Q	TCGA-09-2044	OV	TCGA	LIPYQD	LIG_APCC_ABBA_1	0.7035
p.P761Q	TCGA-A5-A0G2	UCEC	TCGA	LIPYQD	LIG_APCC_ABBA_1	0.7035
p.P761Q	DO28923	OV	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.7035
p.P761Q	DO41235	UCEC	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.7035
p.R750Q	TCGA-AA-3984	COAD	TCGA	LIPYQD	LIG_APCC_ABBA_1	0.0833
p.R750Q	DO9002	COAD	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.0833
p.R750Q	DO233203	GACA	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.0833
p.R750Q	DO233731	GACA	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.0833
p.P766T	TCGA-L5-A4OI	ESCA	TCGA	LIPYQD	LIG_APCC_ABBA_1	0.2778
p.P753S	DO229018	LICA	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.1667
p.P761S	DO222749	MELA	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.6752
p.P761L	DO222908	MELA	ICGC	LIPYQD	LIG_APCC_ABBA_1	0.6471
p.A774V	SIDM00216	Colorectal Carcinoma	GDSC	LIPYQD	LIG_APCC_ABBA_1	0.0556
p.A774V	ACH-000989	Colon/Colorectal Cancer	CCLE	LIPYQD	LIG_APCC_ABBA_1	0.0556
p.A774V	SNU-175	large_intestine	COSMIC	LIPYQD	LIG_APCC_ABBA_1	0.0556
p.S772F	ACH-001366	Neuroblastoma	CCLE	LIPYQD	LIG_APCC_ABBA_1	0.1111
p.Q763E	ACH-001864	Bile Duct Cancer	CCLE	LIPYQD	LIG_APCC_ABBA_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUA4	General transcription factor 3C polypeptide 2	LIG_APCC_ABBA_1	759:764	LIPYQD	APC,CDC20,FZR1	0.8786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons