DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: DEG_APCC_KENBOX_2

Location: 80:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 99.02

COIL: 0.5038

CONS_SCORE: 0.3835

DSS_SCORE: 0.6045

HELIX: 0.4654

FCONS_SCORE: 1.2006

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M78I	TCGA-EE-A2MD	SKCM	TCGA	DKENM	DEG_APCC_KENBOX_2	0.2778
p.K70T	TCGA-EO-A22X	UCEC	TCGA	DKENM	DEG_APCC_KENBOX_2	0.5
p.V71A	TCGA-GF-A6C8	SKCM	TCGA	DKENM	DEG_APCC_KENBOX_2	0.0833
p.P79L	DO3500	BRCA	ICGC	DKENM	DEG_APCC_KENBOX_2	0.3056
p.N76I	DO8463	COAD	ICGC	DKENM	DEG_APCC_KENBOX_2	0.2222
p.S75R	DO41584	UCEC	ICGC	DKENM	DEG_APCC_KENBOX_2	0.3056
p.S90N	SIDM01090	Colorectal Carcinoma	GDSC	DKENM	DEG_APCC_KENBOX_2	0.1667
p.S90N	ACH-000943	Colon/Colorectal Cancer	CCLE	DKENM	DEG_APCC_KENBOX_2	0.1667
p.S90N	RKO	large_intestine	COSMIC	DKENM	DEG_APCC_KENBOX_2	0.1667
p.L74R	SIDM01060	Melanoma	GDSC	DKENM	DEG_APCC_KENBOX_2	0.1667
p.L74R	ACH-000882	Skin Cancer	CCLE	DKENM	DEG_APCC_KENBOX_2	0.1667
p.L74R	IGR-1	skin	COSMIC	DKENM	DEG_APCC_KENBOX_2	0.1667
p.L73R	IGR-1	skin	COSMIC	DKENM	DEG_APCC_KENBOX_2	0.5833
p.S89N	RKO	large_intestine	COSMIC	DKENM	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWK9	Cytoskeleton-associated protein 2	DEG_APCC_KENBOX_2	80:84	DKENM	APC,CDC20,FZR1	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons