DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 555:561

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5207

ASA_SCORE: 108.4429

COIL: 0.3961

CONS_SCORE: 0.3351

DSS_SCORE: 0.4916

HELIX: 0.4597

FCONS_SCORE: 1.0569

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D561E	TCGA-AP-A1DK	UCEC	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.5647
p.L553R	TCGA-C8-A133	BRCA	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K546Q	TCGA-CA-6718	COAD	TCGA	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L552R	DO1926	BRCA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.6944
p.K545Q	DO7801	COAD	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.0556
p.C561F	DO229031	LICA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.7108
p.H553Y	DO222868	MELA	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D560E	DO42033	UCEC	ICGC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.6758
p.L547R	SIDM00079	Ovarian Carcinoma	GDSC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L547R	ACH-000811	Ovarian Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L547R	SK-OV-3	ovary	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H554Y	SIDM01397	Melanoma	GDSC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H554Y	ACH-000765	Skin Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L557S	ACH-002396	Bone Cancer	CCLE	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.6556
p.L557S	Sarc9371	bone	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.6556
p.S546P	GP5d	large_intestine	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L546R	SK-OV-3	ovary	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L556S	Sarc9371	bone	COSMIC	RNLLFQD	LIG_APCC_ABBAyCdc20_2	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWK9	Cytoskeleton-associated protein 2	LIG_APCC_ABBAyCdc20_2	555:561	RNLLFQD	APC,CDC20,FZR1	0.5207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons