DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: DEG_SCF_FBW7_2

Location: 577:583

E3 ligase: FBXW7

DEGRON score: 0.5146

ASA_SCORE: 93.9857

COIL: 0.8477

CONS_SCORE: 0.2782

DSS_SCORE: 0.5264

HELIX: 0.076

FCONS_SCORE: 0.7112

RIG_SCORE: 0.7106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N581S	TCGA-13-1499	OV	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.5958
p.T584M	TCGA-AX-A0J1	UCEC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.3056
p.T584M	TCGA-CA-6717	COAD	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.3056
p.E583K	TCGA-C5-A1MH	CESC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.7022
p.T584A	TCGA-CV-5966	HNSC	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.3056
p.P573A	TCGA-GC-A6I3	BLCA	TCGA	VKTPNTE	DEG_SCF_FBW7_2	0.2222
p.P572A	DO219025	BLCA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.1944
p.E582K	DO48982	CESC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.7022
p.T583M	DO8264	COAD	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.7423
p.T583M	DO41199	UCEC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.7423
p.T583A	DO14950	HNSC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.7139
p.H574R	DO228202	LICA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.25
p.S586I	DO229031	LICA	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.25
p.N580S	DO31563	OV	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.7069
p.V593M	DO42384	UCEC	ICGC	VKTPNTE	DEG_SCF_FBW7_2	0.0556
p.T574I	SIDM00039	Ovarian Carcinoma	GDSC	VKTPNTE	DEG_SCF_FBW7_2	0.25
p.T579S	ACH-000779	Lung Cancer	CCLE	VKTPNTE	DEG_SCF_FBW7_2	0.8227
p.R581C	G-MEL	skin	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	0.8301
p.E584K	GP5d	large_intestine	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	0.3056
p.R580Q	HT-115	large_intestine	COSMIC	VKTPNTE	DEG_SCF_FBW7_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SCF_FBW7_2	577:583	VKTPNTE	FBXW7	0.5146	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons