DegronMD

Uniprot ID: Q8WWK9

Source protein: Cytoskeleton-associated protein 2

Source gene: CKAP2

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.9787

ASA_SCORE: 91.18

COIL: 0.8964

CONS_SCORE: 0.3229

DSS_SCORE: 0.6031

HELIX: 0.0498

FCONS_SCORE: 0.9986

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P213H	TCGA-BH-A0C0	BRCA	TCGA	VNTSS	DEG_SPOP_SBC_1	0.1111
p.R216W	DO14198	HNSC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1944
p.R233L	DO228948	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1111
p.G235W	DO46957	RECA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0556
p.G222D	DO43755	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.7198
p.T211S	SIDM01491	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.5
p.T211S	ACH-000342	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.5
p.P220H	ACH-001369	Ovarian Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.3056
p.R233W	22RV1	prostate	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.1111
p.R233Q	SNG-M	endometrium	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09619	Platelet-derived growth factor receptor beta	DEG_SPOP_SBC_1	1052:1056	VNTSS	SPOP	0.9079	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	369:373	VNTSS	SPOP	0.9386	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	145:149	VNTSS	SPOP	0.9158	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	221:225	VNTSS	SPOP	0.9787	More...
Q9H6R7	WD repeat and coiled-coil-containing protein	DEG_SPOP_SBC_1	482:486	VNTSS	SPOP	0.7588	More...
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_SPOP_SBC_1	154:158	VNTSS	SPOP	0.9935	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	456:460	VNTSS	SPOP	0.7805	More...
Q6Q759	Sperm-associated antigen 17	DEG_SPOP_SBC_1	11:15	VNTSS	SPOP	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons