DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VNTSS
Uniprot ID:
Q8IZP9
Source protein:
Adhesion G-protein coupled receptor G2
Source gene:
ADGRG2
Class:
DEG_SPOP_SBC_1
Location:
369:373
E3 ligase:
SPOP
DEGRON score:
0.9386
ASA_SCORE:
68.28
COIL:
0.8854
CONS_SCORE:
0.4406
DSS_SCORE:
0.4454
HELIX:
0.0536
FCONS_SCORE:
1.0388
RIG_SCORE:
0.7664
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A361T
SIDM00596
Endometrial Carcinoma
GDSC
VNTSS
DEG_SPOP_SBC_1
0.1111
p.A361T
HEC-1
endometrium
COSMIC
VNTSS
DEG_SPOP_SBC_1
0.1111
Drug responses associated with ADGRG2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VNTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P09619
Platelet-derived growth factor receptor beta
DEG_SPOP_SBC_1
1052:1056
VNTSS
SPOP
0.9079
More...
Q8IZP9
Adhesion G-protein coupled receptor G2
DEG_SPOP_SBC_1
369:373
VNTSS
SPOP
0.9386
More...
Q8TAX7
Mucin-7
DEG_SPOP_SBC_1
145:149
VNTSS
SPOP
0.9158
More...
Q8WWK9
Cytoskeleton-associated protein 2
DEG_SPOP_SBC_1
221:225
VNTSS
SPOP
0.9787
More...
Q9H6R7
WD repeat and coiled-coil-containing protein
DEG_SPOP_SBC_1
482:486
VNTSS
SPOP
0.7588
More...
O94913
Pre-mRNA cleavage complex 2 protein Pcf11
DEG_SPOP_SBC_1
154:158
VNTSS
SPOP
0.9935
More...
Q96KR1
Zinc finger RNA-binding protein
DEG_SPOP_SBC_1
456:460
VNTSS
SPOP
0.7805
More...
Q6Q759
Sperm-associated antigen 17
DEG_SPOP_SBC_1
11:15
VNTSS
SPOP
0.8744
More...