DegronMD

Uniprot ID: O94913

Source protein: Pre-mRNA cleavage complex 2 protein Pcf11

Source gene: PCF11

Class: DEG_SPOP_SBC_1

Location: 154:158

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 77.78

COIL: 0.9096

CONS_SCORE: 0.3215

DSS_SCORE: 0.393

HELIX: 0.028

FCONS_SCORE: 0.7544

RIG_SCORE: 0.6667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T156M	TCGA-AP-A051	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	0.7423
p.T156M	DO232761	PBCA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.7423
p.T156M	DO42673	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.7423
p.P163T	TCGA-EE-A29G	SKCM	TCGA	VNTSS	DEG_SPOP_SBC_1	0.1944
p.P163T	DO47303	SKCM	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1944
p.P163H	TCGA-GN-A262	SKCM	TCGA	VNTSS	DEG_SPOP_SBC_1	0.1944
p.P163H	DO37515	SKCM	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1944
p.V154A	DO230343	COCA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.5825
p.A144V	DO231837	LINC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0556
p.N162Y	DO228176	PBCA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.2222
p.P146R	SIDM00704	Small Cell Lung Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.1111
p.P146R	ACH-000639	Lung Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.1111
p.P146R	NCI-H211	lung	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09619	Platelet-derived growth factor receptor beta	DEG_SPOP_SBC_1	1052:1056	VNTSS	SPOP	0.9079	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	369:373	VNTSS	SPOP	0.9386	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	145:149	VNTSS	SPOP	0.9158	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	221:225	VNTSS	SPOP	0.9787	More...
Q9H6R7	WD repeat and coiled-coil-containing protein	DEG_SPOP_SBC_1	482:486	VNTSS	SPOP	0.7588	More...
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_SPOP_SBC_1	154:158	VNTSS	SPOP	0.9935	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	456:460	VNTSS	SPOP	0.7805	More...
Q6Q759	Sperm-associated antigen 17	DEG_SPOP_SBC_1	11:15	VNTSS	SPOP	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons