DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VNTSS
Uniprot ID:
Q9H6R7
Source protein:
WD repeat and coiled-coil-containing protein
Source gene:
WDCP
Class:
DEG_SPOP_SBC_1
Location:
482:486
E3 ligase:
SPOP
DEGRON score:
0.7588
ASA_SCORE:
72.5
COIL:
0.6076
CONS_SCORE:
0.4084
DSS_SCORE:
0.4797
HELIX:
0.0354
FCONS_SCORE:
0.8781
RIG_SCORE:
0.7419
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WDCP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VNTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P09619
Platelet-derived growth factor receptor beta
DEG_SPOP_SBC_1
1052:1056
VNTSS
SPOP
0.9079
More...
Q8IZP9
Adhesion G-protein coupled receptor G2
DEG_SPOP_SBC_1
369:373
VNTSS
SPOP
0.9386
More...
Q8TAX7
Mucin-7
DEG_SPOP_SBC_1
145:149
VNTSS
SPOP
0.9158
More...
Q8WWK9
Cytoskeleton-associated protein 2
DEG_SPOP_SBC_1
221:225
VNTSS
SPOP
0.9787
More...
Q9H6R7
WD repeat and coiled-coil-containing protein
DEG_SPOP_SBC_1
482:486
VNTSS
SPOP
0.7588
More...
O94913
Pre-mRNA cleavage complex 2 protein Pcf11
DEG_SPOP_SBC_1
154:158
VNTSS
SPOP
0.9935
More...
Q96KR1
Zinc finger RNA-binding protein
DEG_SPOP_SBC_1
456:460
VNTSS
SPOP
0.7805
More...
Q6Q759
Sperm-associated antigen 17
DEG_SPOP_SBC_1
11:15
VNTSS
SPOP
0.8744
More...