DegronMD - Q6Q759(SPAG17)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1684L	TCGA-18-3409	LUSC	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1111
p.P1684L	DO26444	LUSC	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1111
p.F1959S	TCGA-26-6174	GBM	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1667
p.F1959S	DO11076	GBM	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1667
p.E1215K	TCGA-3N-A9WC	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.7022
p.E1215K	DO51234	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.7022
p.P1961L	TCGA-43-7656	LUSC	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.2222
p.P1961L	DO26424	LUSC	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.2222
p.T108M	TCGA-A6-3810	COAD	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.T108M	DO9434	COAD	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.S15Y	TCGA-AA-3510	COAD	TCGA	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.712
p.S15Y	DO7783	COAD	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.712
p.S15Y	SIDM00193	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.712
p.S15Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.712
p.S15Y	SNU-81	large intestine	COSMIC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.712
p.A1698E	TCGA-AA-3688	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.3056
p.A1698E	DO8746	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.3056
p.A1698E	DO229027	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.3056
p.E1706D	TCGA-AA-3815	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.0833
p.E1706D	DO9924	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.0833
p.R1693C	TCGA-AZ-6598	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.719
p.R1693C	DO10276	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.719
p.R1693C	DO222527	MELA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.719
p.R1693C	DO46739	PACA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.719
p.I113V	TCGA-B5-A0JZ	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.I113V	DO42761	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.2778
p.E1206D	TCGA-BR-8589	STAD	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0833
p.E1206D	DO47813	STAD	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0833
p.E1206D	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0833
p.E1206D	ACH-002307	Lymphoma	CCLE	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0833
p.E1206D	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0833
p.K130T	TCGA-BS-A0UF	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation substituting flanking lysine	0.1944
p.K130T	DO41488	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation substituting flanking lysine	0.1944
p.P2189S	TCGA-CM-5861	COAD	TCGA	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1667
p.P2189S	DO7918	COAD	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1667
p.D1958Y	TCGA-D3-A3CE	SKCM	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1389
p.R2188Q	TCGA-DA-A1HV	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1389
p.R2188Q	DO37659	SKCM	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1389
p.F1959V	TCGA-DF-A2KU	UCEC	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1667
p.S1971G	TCGA-DH-5143	LGG	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5882
p.S1971G	DO22247	LGG	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5882
p.T121A	TCGA-DI-A1BU	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.7139
p.T121A	DO42023	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.7139
p.D1983Y	TCGA-DR-A0ZM	CESC	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1111
p.D1983Y	DO6254	CESC	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1111
p.E1215D	TCGA-DY-A0XA	READ	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.5647
p.E1215D	DO37026	READ	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.5647
p.E1205K	TCGA-EE-A29S	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0556
p.E1205K	TCGA-GN-A263	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0556
p.E1205K	DO37766	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0556
p.E1205K	DO37936	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.0556
p.P1211L	TCGA-EE-A2GB	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.2222
p.P1211L	DO222683	MELA	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.2222
p.P1211L	DO37417	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.2222
p.P1978L	TCGA-ER-A194	SKCM	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.25
p.P1978L	DO47646	SKCM	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.25
p.D115N	TCGA-ER-A19H	SKCM	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.6932
p.D115N	DO47299	SKCM	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.6932
p.I2207M	TCGA-EY-A1GD	UCEC	TCGA	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1111
p.I2207M	DO42129	UCEC	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1111
p.A2V	TCGA-IB-7651	PAAD	TCGA	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.A2V	DO46657	PAAD	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.E1979Q	TCGA-IR-A3LL	CESC	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.2222
p.E1979Q	DO44362	CESC	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.2222
p.P1211T	TCGA-MP-A4TA	LUAD	TCGA	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.2222
p.P1211T	DO45314	LUAD	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.2222
p.S1971R	TCGA-NC-A5HG	LUSC	TCGA	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.6316
p.S1971R	DO45448	LUSC	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.6316
p.G1685S	TCGA-Z2-A8RT	SKCM	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1389
p.G1685S	DO229446	SKCA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1389
p.G1685S	DO51301	SKCM	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1389
p.R1693H	TCGA-ZJ-AAXU	CESC	TCGA	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.7133
p.R1693H	DO219759	CESC	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.7133
p.K5N	DO225230	BRCA	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation substituting flanking lysine	0.2778
p.K2187I	DO228551	GACA	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation substituting flanking lysine	0.2222
p.K1963T	DO218243	GACA	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.2778
p.P2199T	DO228976	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation altering degron motif	0.5919
p.P1700T	DO228986	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.25
p.A110E	DO229018	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1944
p.T1221N	DO229019	LICA	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.7055
p.L22I	DO229019	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.P20H	DO229015	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.L128I	DO229015	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.1389
p.P1220H	DO229028	LICA	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation altering degron motif	0.7694
p.Q1967K	DO229022	LICA	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5833
p.Q1967K	SIDM00120	Prostate Carcinoma	GDSC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5833
p.Q1967K	ACH-000979	Prostate Cancer	CCLE	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5833
p.Q1967K	DU-145	prostate	COSMIC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5833
p.A2T	DO229030	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.F1695L	DO229037	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.6981
p.A112E	DO229037	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.25
p.A24D	DO229045	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.A24D	DO228858	MALY	ICGC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.FH1695FY	DO222749	MELA	ICGC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation altering degron motif	0.7528
p.V1227G	DO222749	MELA	ICGC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.1944
p.P2199Q	DO32900	PACA	ICGC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation altering degron motif	0.5924
p.K1968N	DO227581	PACA	ICGC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation altering degron motif	0.5806
p.Q1214E	SIDM00521	Small Cell Lung Carcinoma	GDSC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.3056
p.Q1214E	ACH-000743	Lung Cancer	CCLE	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.3056
p.Q1214E	COR-L95	lung	COSMIC	ETLDVPTF	DEG_COP1_1	1215:1222	Mutation rewiring degron network	0.3056
p.M114L	SIDM00646	Small Cell Lung Carcinoma	GDSC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.M114L	ACH-000129	Lung Cancer	CCLE	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.M114L	NCI-H1341	lung	COSMIC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation rewiring degron network	0.3056
p.S15F	SIDM00007	Other Solid Cancers	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7982
p.S15F	ACH-001550	Skin Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7982
p.S15F	MCC13	skin	COSMIC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7982
p.W18R	SIDM00457	Plasma Cell Myeloma	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	SIDM00970	Bladder Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	SIDM01377	Ovarian Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	ACH-000024	Myeloma	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	ACH-000409	Ovarian Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	ACH-002235	Bladder Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	DSH1	urinary tract	COSMIC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.W18R	OPM-2	haematopoietic and lymphoid tissue	COSMIC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.S116G	SIDM00282	Colorectal Carcinoma	GDSC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.6993
p.S116G	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.6993
p.S116G	CW-2	large intestine	COSMIC	DSGEKLT	DEG_SCF_TRCP1_1	115:121	Mutation altering degron motif	0.6993
p.V2201L	SIDM01056	Breast Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.2778
p.V2201L	ACH-000330	Breast Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.2778
p.V2201L	EFM-19	breast	COSMIC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.2778
p.E1706K	SIDM00006	Other Solid Cancers	GDSC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.0833
p.E1706K	ACH-001552	Skin Cancer	CCLE	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.0833
p.E1706K	MCC26	skin	COSMIC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.0833
p.A25P	SIDM00217	Colorectal Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0556
p.A25P	ACH-000999	Colon/Colorectal Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0556
p.A25P	SNU-1040	large intestine	COSMIC	VNTSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0556
p.S2205Y	SIDM00008	Ovarian Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1667
p.S2205Y	ACH-000796	Ovarian Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	2195:2199	Mutation rewiring degron network	0.1667
p.L1957I	SIDM01611	Endometrial Carcinoma	GDSC	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1111
p.L1957I	ACH-000996	Endometrial/Uterine Cancer	CCLE	SEQKSSSVPSL	DEG_COP1_1	1965:1975	Mutation rewiring degron network	0.1111
p.T1686S	SIDM01752	Pancreatic Carcinoma	GDSC	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1667
p.T1686S	ACH-000685	Pancreatic Cancer	CCLE	LRPFHE	LIG_APCC_ABBA_1	1692:1697	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG17

UniProt ID: Q6Q759

Entrez ID: 200162

Protein name: Sperm-associated antigen 17 (Projection protein PF6 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG17 in