DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: DEG_COP1_1

Location: 1965:1975

E3 ligase: COP1

DEGRON score: 0.9753

ASA_SCORE: 92.9091

COIL: 0.8747

CONS_SCORE: 0.293

DSS_SCORE: 0.6423

HELIX: 0.116

FCONS_SCORE: 1.1305

RIG_SCORE: 0.5947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1959S	TCGA-26-6174	GBM	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.1667
p.F1959S	DO11076	GBM	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.1667
p.P1961L	TCGA-43-7656	LUSC	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.2222
p.P1961L	DO26424	LUSC	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.2222
p.D1958Y	TCGA-D3-A3CE	SKCM	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.1389
p.F1959V	TCGA-DF-A2KU	UCEC	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.1667
p.S1971G	TCGA-DH-5143	LGG	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.5882
p.S1971G	DO22247	LGG	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.5882
p.D1983Y	TCGA-DR-A0ZM	CESC	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.1111
p.D1983Y	DO6254	CESC	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.1111
p.P1978L	TCGA-ER-A194	SKCM	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.25
p.P1978L	DO47646	SKCM	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.25
p.E1979Q	TCGA-IR-A3LL	CESC	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.2222
p.E1979Q	DO44362	CESC	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.2222
p.S1971R	TCGA-NC-A5HG	LUSC	TCGA	SEQKSSSVPSL	DEG_COP1_1	0.6316
p.S1971R	DO45448	LUSC	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.6316
p.K1963T	DO218243	GACA	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.2778
p.Q1967K	DO229022	LICA	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.5833
p.Q1967K	SIDM00120	Prostate Carcinoma	GDSC	SEQKSSSVPSL	DEG_COP1_1	0.5833
p.Q1967K	ACH-000979	Prostate Cancer	CCLE	SEQKSSSVPSL	DEG_COP1_1	0.5833
p.Q1967K	DU-145	prostate	COSMIC	SEQKSSSVPSL	DEG_COP1_1	0.5833
p.K1968N	DO227581	PACA	ICGC	SEQKSSSVPSL	DEG_COP1_1	0.5806
p.L1957I	SIDM01611	Endometrial Carcinoma	GDSC	SEQKSSSVPSL	DEG_COP1_1	0.1111
p.L1957I	ACH-000996	Endometrial/Uterine Cancer	CCLE	SEQKSSSVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q759	Sperm-associated antigen 17	DEG_COP1_1	1965:1975	SEQKSSSVPSL	COP1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons