DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: DEG_SCF_TRCP1_1

Location: 115:121

E3 ligase: BTRC

DEGRON score: 0.5664

ASA_SCORE: 76.2714

COIL: 0.8164

CONS_SCORE: 0.4081

DSS_SCORE: 0.0728

HELIX: 0.0837

FCONS_SCORE: 0.8442

RIG_SCORE: 0.8233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T108M	TCGA-A6-3810	COAD	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	0.1389
p.T108M	DO9434	COAD	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.1389
p.I113V	TCGA-B5-A0JZ	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	0.2778
p.I113V	DO42761	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.2778
p.K130T	TCGA-BS-A0UF	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	0.1944
p.K130T	DO41488	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.1944
p.T121A	TCGA-DI-A1BU	UCEC	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	0.7139
p.T121A	DO42023	UCEC	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.7139
p.D115N	TCGA-ER-A19H	SKCM	TCGA	DSGEKLT	DEG_SCF_TRCP1_1	0.6932
p.D115N	DO47299	SKCM	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.6932
p.A110E	DO229018	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.1944
p.L128I	DO229015	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.1389
p.A112E	DO229037	LICA	ICGC	DSGEKLT	DEG_SCF_TRCP1_1	0.25
p.M114L	SIDM00646	Small Cell Lung Carcinoma	GDSC	DSGEKLT	DEG_SCF_TRCP1_1	0.3056
p.M114L	ACH-000129	Lung Cancer	CCLE	DSGEKLT	DEG_SCF_TRCP1_1	0.3056
p.M114L	NCI-H1341	lung	COSMIC	DSGEKLT	DEG_SCF_TRCP1_1	0.3056
p.S116G	SIDM00282	Colorectal Carcinoma	GDSC	DSGEKLT	DEG_SCF_TRCP1_1	0.6993
p.S116G	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGEKLT	DEG_SCF_TRCP1_1	0.6993
p.S116G	CW-2	large_intestine	COSMIC	DSGEKLT	DEG_SCF_TRCP1_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q759	Sperm-associated antigen 17	DEG_SCF_TRCP1_1	115:121	DSGEKLT	BTRC	0.5664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons