DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: DEG_APCC_KENBOX_2

Location: 2195:2199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7302

ASA_SCORE: 79.12

COIL: 0.8316

CONS_SCORE: 0.2807

DSS_SCORE: 0.6132

HELIX: 0.0504

FCONS_SCORE: 0.9399

RIG_SCORE: 0.6859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2189S	TCGA-CM-5861	COAD	TCGA	GKENP	DEG_APCC_KENBOX_2	0.1667
p.P2189S	DO7918	COAD	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1667
p.R2188Q	TCGA-DA-A1HV	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.1389
p.R2188Q	DO37659	SKCM	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1389
p.I2207M	TCGA-EY-A1GD	UCEC	TCGA	GKENP	DEG_APCC_KENBOX_2	0.1111
p.I2207M	DO42129	UCEC	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1111
p.K2187I	DO228551	GACA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2222
p.P2199T	DO228976	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.5919
p.P2199Q	DO32900	PACA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.5924
p.V2201L	SIDM01056	Breast Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.2778
p.V2201L	ACH-000330	Breast Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	0.2778
p.V2201L	EFM-19	breast	COSMIC	GKENP	DEG_APCC_KENBOX_2	0.2778
p.S2205Y	SIDM00008	Ovarian Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.1667
p.S2205Y	ACH-000796	Ovarian Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28039	Acyloxyacyl hydrolase	DEG_APCC_KENBOX_2	556:560	GKENP	APC,CDC20,FZR1	0.6187	More...
Q5K651	Sterile alpha motif domain-containing protein 9	DEG_APCC_KENBOX_2	116:120	GKENP	APC,CDC20,FZR1	0.7712	More...
Q5VTB9	E3 ubiquitin-protein ligase RNF220	DEG_APCC_KENBOX_2	384:388	GKENP	APC,CDC20,FZR1	0.7646	More...
Q6Q759	Sperm-associated antigen 17	DEG_APCC_KENBOX_2	2195:2199	GKENP	APC,CDC20,FZR1	0.7302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons