DegronMD - P28039(AOAH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P560Q	TCGA-09-2044	OV	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.5924
p.P560A	TCGA-56-8307	LUSC	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.6392
p.V568L	TCGA-66-2781	LUSC	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.1111
p.Q553K	TCGA-D3-A2JC	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.25
p.E558K	TCGA-D3-A8GV	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.7022
p.E558K	TCGA-WE-AAA0	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.7022
p.G556E	TCGA-GF-A6C9	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.6087
p.D568N	DO222884	COCA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.1111
p.N564S	DO233649	GACA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.2222
p.T558K	DO228974	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation altering degron motif	0.7306
p.T548K	DO228985	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.1111
p.T548K	DO229008	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.1111
p.Q552K	DO229034	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation rewiring degron network	0.2222
p.S546I	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation substituting flanking lysine	0.1667
p.S546I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation substituting flanking lysine	0.1667
p.S546I	U-698-M	haematopoietic and lymphoid tissue	COSMIC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation substituting flanking lysine	0.1667
p.S546I	NCI-H650	lung	COSMIC	GKENP	DEG_APCC_KENBOX_2	556:560	Mutation substituting flanking lysine	0.1667

Kaplan plot for AOAH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AOAH

UniProt ID: P28039

Entrez ID: 313

Protein name: Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AOAH in