DegronMD

Uniprot ID: P28039

Source protein: Acyloxyacyl hydrolase

Source gene: AOAH

Class: DEG_APCC_KENBOX_2

Location: 556:560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6187

ASA_SCORE: 70.44

COIL: 0.9046

CONS_SCORE: 0.4782

DSS_SCORE: 0.3623

HELIX: 0.0518

FCONS_SCORE: 1.1721

RIG_SCORE: 0.7506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P560Q	TCGA-09-2044	OV	TCGA	GKENP	DEG_APCC_KENBOX_2	0.5924
p.P560A	TCGA-56-8307	LUSC	TCGA	GKENP	DEG_APCC_KENBOX_2	0.6392
p.V568L	TCGA-66-2781	LUSC	TCGA	GKENP	DEG_APCC_KENBOX_2	0.1111
p.Q553K	TCGA-D3-A2JC	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.25
p.E558K	TCGA-D3-A8GV	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.7022
p.E558K	TCGA-WE-AAA0	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.7022
p.G556E	TCGA-GF-A6C9	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.6087
p.D568N	DO222884	COCA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1111
p.N564S	DO233649	GACA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2222
p.T558K	DO228974	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.7306
p.T548K	DO228985	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1111
p.T548K	DO229008	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.1111
p.Q552K	DO229034	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2222
p.S546I	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.1667
p.S546I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.1667
p.S546I	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	GKENP	DEG_APCC_KENBOX_2	0.1667
p.S546I	NCI-H650	lung	COSMIC	GKENP	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28039	Acyloxyacyl hydrolase	DEG_APCC_KENBOX_2	556:560	GKENP	APC,CDC20,FZR1	0.6187	More...
Q5K651	Sterile alpha motif domain-containing protein 9	DEG_APCC_KENBOX_2	116:120	GKENP	APC,CDC20,FZR1	0.7712	More...
Q5VTB9	E3 ubiquitin-protein ligase RNF220	DEG_APCC_KENBOX_2	384:388	GKENP	APC,CDC20,FZR1	0.7646	More...
Q6Q759	Sperm-associated antigen 17	DEG_APCC_KENBOX_2	2195:2199	GKENP	APC,CDC20,FZR1	0.7302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons