DegronMD

Uniprot ID: Q5K651

Source protein: Sterile alpha motif domain-containing protein 9

Source gene: SAMD9

Class: DEG_APCC_KENBOX_2

Location: 116:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7712

ASA_SCORE: 94.7

COIL: 0.866

CONS_SCORE: 0.3662

DSS_SCORE: 0.8345

HELIX: 0.0936

FCONS_SCORE: 1.1365

RIG_SCORE: 0.5762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q114P	TCGA-D1-A1NY	UCEC	TCGA	GKENP	DEG_APCC_KENBOX_2	0.2778
p.Q114P	DO42512	UCEC	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2778
p.Q112R	TCGA-EE-A2MI	SKCM	TCGA	GKENP	DEG_APCC_KENBOX_2	0.2222
p.Q112R	DO37531	SKCM	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2222
p.R106H	DO222769	COCA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.0556
p.Q114K	DO228948	LICA	ICGC	GKENP	DEG_APCC_KENBOX_2	0.2778
p.K115R	SIDM01612	Endometrial Carcinoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.3056
p.K115R	ACH-000946	Endometrial/Uterine Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	0.3056
p.R106C	SIDM00016	Neuroblastoma	GDSC	GKENP	DEG_APCC_KENBOX_2	0.0556
p.P125S	ACH-002396	Bone Cancer	CCLE	GKENP	DEG_APCC_KENBOX_2	0.1944
p.P125S	Sarc9371	bone	COSMIC	GKENP	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28039	Acyloxyacyl hydrolase	DEG_APCC_KENBOX_2	556:560	GKENP	APC,CDC20,FZR1	0.6187	More...
Q5K651	Sterile alpha motif domain-containing protein 9	DEG_APCC_KENBOX_2	116:120	GKENP	APC,CDC20,FZR1	0.7712	More...
Q5VTB9	E3 ubiquitin-protein ligase RNF220	DEG_APCC_KENBOX_2	384:388	GKENP	APC,CDC20,FZR1	0.7646	More...
Q6Q759	Sperm-associated antigen 17	DEG_APCC_KENBOX_2	2195:2199	GKENP	APC,CDC20,FZR1	0.7302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons