DegronMD - Q5VTB9(RNF220)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P440H	TCGA-66-2789	LUSC	TCGA	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.1944
p.P440H	DO27279	LUSC	ICGC	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.1944
p.D455N	TCGA-AC-A23H	BRCA	TCGA	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.2222
p.D455N	TCGA-AC-A23H	BRCA	TCGA	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.1944
p.D455N	DO2401	BRCA	ICGC	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.2222
p.D455N	DO2401	BRCA	ICGC	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.1944
p.W452C	TCGA-D3-A3CE	SKCM	TCGA	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.1389
p.W452C	TCGA-D3-A3CE	SKCM	TCGA	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.2778
p.W452C	DO37405	SKCM	ICGC	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.1389
p.W452C	DO37405	SKCM	ICGC	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.2778
p.E386Q	TCGA-EW-A1PD	BRCA	TCGA	GKENP	DEG_APCC_KENBOX_2	384:388	Mutation altering degron motif	0.6744
p.E386Q	DO4921	BRCA	ICGC	GKENP	DEG_APCC_KENBOX_2	384:388	Mutation altering degron motif	0.6744
p.A470V	TCGA-FI-A2D0	UCEC	TCGA	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.1667
p.A470V	DO43891	UCEC	ICGC	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.1667
p.T474I	TCGA-HU-8602	STAD	TCGA	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.0556
p.K473E	TCGA-MR-A8JO	LIHC	TCGA	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation substituting flanking lysine	0.1944
p.S465G	SIDM00845	Burkitt's Lymphoma	GDSC	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.3056
p.S465G	SIDM00461	Acute Myeloid Leukemia	GDSC	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.3056
p.S465G	ACH-000786	Lymphoma	CCLE	STSNGE	DEG_Kelch_Keap1_1	459:464	Mutation rewiring degron network	0.3056
p.R444C	SIDM00214	Colorectal Carcinoma	GDSC	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.3056
p.R444C	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.3056
p.R444C	SNU-407	large intestine	COSMIC	ITPEFS	DEG_SCF_FBW7_1	445:450	Mutation rewiring degron network	0.3056

Kaplan plot for RNF220 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF220

UniProt ID: Q5VTB9

Entrez ID: 55182

Protein name: E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF220 in