DegronMD

Uniprot ID: Q5VTB9

Source protein: E3 ubiquitin-protein ligase RNF220

Source gene: RNF220

Class: DEG_SCF_FBW7_1

Location: 445:450

E3 ligase: FBXW7

DEGRON score: 0.99

ASA_SCORE: 72.9667

COIL: 0.638

CONS_SCORE: 0.3414

DSS_SCORE: 0.6468

HELIX: 0.262

FCONS_SCORE: 1.0662

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P440H	TCGA-66-2789	LUSC	TCGA	ITPEFS	DEG_SCF_FBW7_1	0.1944
p.P440H	DO27279	LUSC	ICGC	ITPEFS	DEG_SCF_FBW7_1	0.1944
p.D455N	TCGA-AC-A23H	BRCA	TCGA	ITPEFS	DEG_SCF_FBW7_1	0.1944
p.D455N	DO2401	BRCA	ICGC	ITPEFS	DEG_SCF_FBW7_1	0.1944
p.W452C	TCGA-D3-A3CE	SKCM	TCGA	ITPEFS	DEG_SCF_FBW7_1	0.2778
p.W452C	DO37405	SKCM	ICGC	ITPEFS	DEG_SCF_FBW7_1	0.2778
p.R444C	SIDM00214	Colorectal Carcinoma	GDSC	ITPEFS	DEG_SCF_FBW7_1	0.3056
p.R444C	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPEFS	DEG_SCF_FBW7_1	0.3056
p.R444C	SNU-407	large_intestine	COSMIC	ITPEFS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VTB9	E3 ubiquitin-protein ligase RNF220	DEG_SCF_FBW7_1	445:450	ITPEFS	FBXW7	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons