DegronMD

Uniprot ID: Q5VTB9

Source protein: E3 ubiquitin-protein ligase RNF220

Source gene: RNF220

Class: DEG_Kelch_Keap1_1

Location: 459:464

E3 ligase: KEAP1

DEGRON score: 0.9526

ASA_SCORE: 91.3667

COIL: 0.885

CONS_SCORE: 0.4464

DSS_SCORE: 0.6754

HELIX: 0.0962

FCONS_SCORE: 1.321

RIG_SCORE: 0.5703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D455N	TCGA-AC-A23H	BRCA	TCGA	STSNGE	DEG_Kelch_Keap1_1	0.2222
p.D455N	DO2401	BRCA	ICGC	STSNGE	DEG_Kelch_Keap1_1	0.2222
p.W452C	TCGA-D3-A3CE	SKCM	TCGA	STSNGE	DEG_Kelch_Keap1_1	0.1389
p.W452C	DO37405	SKCM	ICGC	STSNGE	DEG_Kelch_Keap1_1	0.1389
p.A470V	TCGA-FI-A2D0	UCEC	TCGA	STSNGE	DEG_Kelch_Keap1_1	0.1667
p.A470V	DO43891	UCEC	ICGC	STSNGE	DEG_Kelch_Keap1_1	0.1667
p.T474I	TCGA-HU-8602	STAD	TCGA	STSNGE	DEG_Kelch_Keap1_1	0.0556
p.K473E	TCGA-MR-A8JO	LIHC	TCGA	STSNGE	DEG_Kelch_Keap1_1	0.1944
p.S465G	SIDM00845	Burkitt's Lymphoma	GDSC	STSNGE	DEG_Kelch_Keap1_1	0.3056
p.S465G	SIDM00461	Acute Myeloid Leukemia	GDSC	STSNGE	DEG_Kelch_Keap1_1	0.3056
p.S465G	ACH-000786	Lymphoma	CCLE	STSNGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VTB9	E3 ubiquitin-protein ligase RNF220	DEG_Kelch_Keap1_1	459:464	STSNGE	KEAP1	0.9526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons