DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GKENP
Uniprot ID:
Q5VTB9
Source protein:
E3 ubiquitin-protein ligase RNF220
Source gene:
RNF220
Class:
DEG_APCC_KENBOX_2
Location:
384:388
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7646
ASA_SCORE:
86.96
COIL:
0.8494
CONS_SCORE:
0.3594
DSS_SCORE:
0.4592
HELIX:
0.048
FCONS_SCORE:
0.6639
RIG_SCORE:
0.6382
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E386Q
TCGA-EW-A1PD
BRCA
TCGA
GKENP
DEG_APCC_KENBOX_2
0.6744
p.E386Q
DO4921
BRCA
ICGC
GKENP
DEG_APCC_KENBOX_2
0.6744
Drug responses associated with RNF220 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GKENP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P28039
Acyloxyacyl hydrolase
DEG_APCC_KENBOX_2
556:560
GKENP
APC,CDC20,FZR1
0.6187
More...
Q5K651
Sterile alpha motif domain-containing protein 9
DEG_APCC_KENBOX_2
116:120
GKENP
APC,CDC20,FZR1
0.7712
More...
Q5VTB9
E3 ubiquitin-protein ligase RNF220
DEG_APCC_KENBOX_2
384:388
GKENP
APC,CDC20,FZR1
0.7646
More...
Q6Q759
Sperm-associated antigen 17
DEG_APCC_KENBOX_2
2195:2199
GKENP
APC,CDC20,FZR1
0.7302
More...