DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: LIG_APCC_ABBA_1

Location: 1692:1697

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9808

ASA_SCORE: 68.8833

COIL: 0.4823

CONS_SCORE: 0.4516

DSS_SCORE: 0.3364

HELIX: 0.0322

FCONS_SCORE: 1.2848

RIG_SCORE: 0.7903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1684L	TCGA-18-3409	LUSC	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.1111
p.P1684L	DO26444	LUSC	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.1111
p.A1698E	TCGA-AA-3688	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.3056
p.A1698E	DO8746	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.3056
p.A1698E	DO229027	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.3056
p.E1706D	TCGA-AA-3815	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.0833
p.E1706D	DO9924	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.0833
p.R1693C	TCGA-AZ-6598	COAD	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.719
p.R1693C	DO10276	COAD	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.719
p.R1693C	DO222527	MELA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.719
p.R1693C	DO46739	PACA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.719
p.G1685S	TCGA-Z2-A8RT	SKCM	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.1389
p.G1685S	DO229446	SKCA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.1389
p.G1685S	DO51301	SKCM	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.1389
p.R1693H	TCGA-ZJ-AAXU	CESC	TCGA	LRPFHE	LIG_APCC_ABBA_1	0.7133
p.R1693H	DO219759	CESC	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.7133
p.P1700T	DO228986	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.25
p.F1695L	DO229037	LICA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.6981
p.FH1695FY	DO222749	MELA	ICGC	LRPFHE	LIG_APCC_ABBA_1	0.7528
p.E1706K	SIDM00006	Other Solid Cancers	GDSC	LRPFHE	LIG_APCC_ABBA_1	0.0833
p.E1706K	ACH-001552	Skin Cancer	CCLE	LRPFHE	LIG_APCC_ABBA_1	0.0833
p.E1706K	MCC26	skin	COSMIC	LRPFHE	LIG_APCC_ABBA_1	0.0833
p.T1686S	SIDM01752	Pancreatic Carcinoma	GDSC	LRPFHE	LIG_APCC_ABBA_1	0.1667
p.T1686S	ACH-000685	Pancreatic Cancer	CCLE	LRPFHE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q759	Sperm-associated antigen 17	LIG_APCC_ABBA_1	1692:1697	LRPFHE	APC,CDC20,FZR1	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons