DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ETLDVPTF
Uniprot ID:
Q6Q759
Source protein:
Sperm-associated antigen 17
Source gene:
SPAG17
Class:
DEG_COP1_1
Location:
1215:1222
E3 ligase:
COP1
DEGRON score:
0.9429
ASA_SCORE:
76.225
COIL:
0.7904
CONS_SCORE:
0.2697
DSS_SCORE:
0.4585
HELIX:
0.1429
FCONS_SCORE:
0.6734
RIG_SCORE:
0.8031
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1220H
DO229028
LICA
ICGC
ETLDVPTF
DEG_COP1_1
0.7694
p.T1221N
DO229019
LICA
ICGC
ETLDVPTF
DEG_COP1_1
0.7055
p.E1215K
TCGA-3N-A9WC
SKCM
TCGA
ETLDVPTF
DEG_COP1_1
0.7022
p.E1215K
DO51234
SKCM
ICGC
ETLDVPTF
DEG_COP1_1
0.7022
p.E1215D
TCGA-DY-A0XA
READ
TCGA
ETLDVPTF
DEG_COP1_1
0.5647
p.E1215D
DO37026
READ
ICGC
ETLDVPTF
DEG_COP1_1
0.5647
p.Q1214E
SIDM00521
Small Cell Lung Carcinoma
GDSC
ETLDVPTF
DEG_COP1_1
0.3056
p.Q1214E
ACH-000743
Lung Cancer
CCLE
ETLDVPTF
DEG_COP1_1
0.3056
p.Q1214E
COR-L95
lung
COSMIC
ETLDVPTF
DEG_COP1_1
0.3056
p.P1211L
TCGA-EE-A2GB
SKCM
TCGA
ETLDVPTF
DEG_COP1_1
0.2222
p.P1211L
DO222683
MELA
ICGC
ETLDVPTF
DEG_COP1_1
0.2222
p.P1211L
DO37417
SKCM
ICGC
ETLDVPTF
DEG_COP1_1
0.2222
p.P1211T
TCGA-MP-A4TA
LUAD
TCGA
ETLDVPTF
DEG_COP1_1
0.2222
p.P1211T
DO45314
LUAD
ICGC
ETLDVPTF
DEG_COP1_1
0.2222
p.V1227G
DO222749
MELA
ICGC
ETLDVPTF
DEG_COP1_1
0.1944
p.E1206D
TCGA-BR-8589
STAD
TCGA
ETLDVPTF
DEG_COP1_1
0.0833
p.E1206D
DO47813
STAD
ICGC
ETLDVPTF
DEG_COP1_1
0.0833
p.E1206D
SIDM00404
B-Cell Non-Hodgkin's Lymphoma
GDSC
ETLDVPTF
DEG_COP1_1
0.0833
p.E1206D
ACH-002307
Lymphoma
CCLE
ETLDVPTF
DEG_COP1_1
0.0833
p.E1206D
SU-DHL-16
haematopoietic_and_lymphoid_tissue
COSMIC
ETLDVPTF
DEG_COP1_1
0.0833
p.E1205K
TCGA-EE-A29S
SKCM
TCGA
ETLDVPTF
DEG_COP1_1
0.0556
p.E1205K
TCGA-GN-A263
SKCM
TCGA
ETLDVPTF
DEG_COP1_1
0.0556
p.E1205K
DO37766
SKCM
ICGC
ETLDVPTF
DEG_COP1_1
0.0556
p.E1205K
DO37936
SKCM
ICGC
ETLDVPTF
DEG_COP1_1
0.0556
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Drug responses associated with SPAG17 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of ETLDVPTF
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6Q759
Sperm-associated antigen 17
DEG_COP1_1
1215:1222
ETLDVPTF
COP1
0.9429
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