DegronMD

Uniprot ID: Q6Q759

Source protein: Sperm-associated antigen 17

Source gene: SPAG17

Class: DEG_COP1_1

Location: 1215:1222

E3 ligase: COP1

DEGRON score: 0.9429

ASA_SCORE: 76.225

COIL: 0.7904

CONS_SCORE: 0.2697

DSS_SCORE: 0.4585

HELIX: 0.1429

FCONS_SCORE: 0.6734

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1215K	TCGA-3N-A9WC	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	0.7022
p.E1215K	DO51234	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	0.7022
p.E1206D	TCGA-BR-8589	STAD	TCGA	ETLDVPTF	DEG_COP1_1	0.0833
p.E1206D	DO47813	STAD	ICGC	ETLDVPTF	DEG_COP1_1	0.0833
p.E1206D	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	ETLDVPTF	DEG_COP1_1	0.0833
p.E1206D	ACH-002307	Lymphoma	CCLE	ETLDVPTF	DEG_COP1_1	0.0833
p.E1206D	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	ETLDVPTF	DEG_COP1_1	0.0833
p.E1215D	TCGA-DY-A0XA	READ	TCGA	ETLDVPTF	DEG_COP1_1	0.5647
p.E1215D	DO37026	READ	ICGC	ETLDVPTF	DEG_COP1_1	0.5647
p.E1205K	TCGA-EE-A29S	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	0.0556
p.E1205K	TCGA-GN-A263	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	0.0556
p.E1205K	DO37766	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	0.0556
p.E1205K	DO37936	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	0.0556
p.P1211L	TCGA-EE-A2GB	SKCM	TCGA	ETLDVPTF	DEG_COP1_1	0.2222
p.P1211L	DO222683	MELA	ICGC	ETLDVPTF	DEG_COP1_1	0.2222
p.P1211L	DO37417	SKCM	ICGC	ETLDVPTF	DEG_COP1_1	0.2222
p.P1211T	TCGA-MP-A4TA	LUAD	TCGA	ETLDVPTF	DEG_COP1_1	0.2222
p.P1211T	DO45314	LUAD	ICGC	ETLDVPTF	DEG_COP1_1	0.2222
p.T1221N	DO229019	LICA	ICGC	ETLDVPTF	DEG_COP1_1	0.7055
p.P1220H	DO229028	LICA	ICGC	ETLDVPTF	DEG_COP1_1	0.7694
p.V1227G	DO222749	MELA	ICGC	ETLDVPTF	DEG_COP1_1	0.1944
p.Q1214E	SIDM00521	Small Cell Lung Carcinoma	GDSC	ETLDVPTF	DEG_COP1_1	0.3056
p.Q1214E	ACH-000743	Lung Cancer	CCLE	ETLDVPTF	DEG_COP1_1	0.3056
p.Q1214E	COR-L95	lung	COSMIC	ETLDVPTF	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q759	Sperm-associated antigen 17	DEG_COP1_1	1215:1222	ETLDVPTF	COP1	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons