DegronMD - Q8IZP9(ADGRG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V350M	SIDM01295	Pancreatic Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1667
p.P348L	SIDM00458	Acute Myeloid Leukemia	GDSC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.P348L	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.P348T	SIDM00458	Acute Myeloid Leukemia	GDSC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.P348T	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.R266W	SIDM00773	Non-Cancerous	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00967	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00210	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00694	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00971	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00849	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00068	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00774	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM00785	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R266W	SIDM01318	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.R999C	SIDM00234	Other Solid Cancers	GDSC	KRGSLHFIE	DEG_APCC_DBOX_1	1007:1015	Mutation rewiring degron network	0.1111
p.R999C	TC-YIK	cervix	COSMIC	KRGSLHFIE	DEG_APCC_DBOX_1	1007:1015	Mutation rewiring degron network	0.1111
p.S935C	SIDM00845	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	SIDM00461	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	SIDM01519	Head and Neck Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.S935C	DND-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1389
p.R999H	SIDM00198	Ewing's Sarcoma	GDSC	KRGSLHFIE	DEG_APCC_DBOX_1	1007:1015	Mutation rewiring degron network	0.1111
p.R999H	EW-16	bone	COSMIC	KRGSLHFIE	DEG_APCC_DBOX_1	1007:1015	Mutation rewiring degron network	0.1111
p.A247T	SIDM00523	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.A247T	DMS-53	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.A361T	SIDM00596	Endometrial Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.3056
p.A361T	SIDM00596	Endometrial Carcinoma	GDSC	VNTSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.A361T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.3056
p.A361T	HEC-1	endometrium	COSMIC	VNTSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.S928P	SIDM00837	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation altering degron motif	0.6752
p.S928P	SW48	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation altering degron motif	0.6752
p.V356F	SIDM00560	Gastric Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7068
p.V356F	MKN7	stomach	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7068
p.A247D	SIDM01173	Rhabdomyosarcoma	GDSC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.G914C	SIDM01608	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.0556
p.N929T	SIDM01588	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.3056
p.S919C	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1944
p.S919C	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1944
p.S919C	DND-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1944
p.N923S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.3056
p.S932C	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.2222
p.S932C	DND-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.2222
p.S932C	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.2222
p.S914P	SW48	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.0556
p.S921C	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.25
p.S921C	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.25
p.S921C	DND-41	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.25
p.A244T	DMS-53	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.N925S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation altering degron motif	0.7069
p.S925P	SW48	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation altering degron motif	0.5641
p.N917S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation substituting flanking lysine	0.25
p.A358T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7139
p.N931S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.25
p.A347T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0833
p.V353F	MKN7	stomach	COSMIC	VNTTS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.25
p.N933S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	924:928	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRG2

UniProt ID: Q8IZP9

Entrez ID: 10149

Protein name: Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRG2 in