DegronMD

Uniprot ID: Q8IZP9

Source protein: Adhesion G-protein coupled receptor G2

Source gene: ADGRG2

Class: DEG_APCC_DBOX_1

Location: 1007:1015

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9542

ASA_SCORE: 107

COIL: 0.7643

CONS_SCORE: 0.2121

DSS_SCORE: 0.6942

HELIX: 0.1341

FCONS_SCORE: 1.0116

RIG_SCORE: 0.7336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R999C	SIDM00234	Other Solid Cancers	GDSC	KRGSLHFIE	DEG_APCC_DBOX_1	0.1111
p.R999C	TC-YIK	cervix	COSMIC	KRGSLHFIE	DEG_APCC_DBOX_1	0.1111
p.R999H	SIDM00198	Ewing's Sarcoma	GDSC	KRGSLHFIE	DEG_APCC_DBOX_1	0.1111
p.R999H	EW-16	bone	COSMIC	KRGSLHFIE	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_APCC_DBOX_1	1007:1015	KRGSLHFIE	APC,CDC20,FZR1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons