DegronMD

Uniprot ID: Q8IZP9

Source protein: Adhesion G-protein coupled receptor G2

Source gene: ADGRG2

Class: DEG_SPOP_SBC_1

Location: 254:258

E3 ligase: SPOP

DEGRON score: 0.786

ASA_SCORE: 81.8

COIL: 0.9012

CONS_SCORE: 0.4316

DSS_SCORE: 0.5117

HELIX: 0.0366

FCONS_SCORE: 1.0611

RIG_SCORE: 0.6105

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A247T	SIDM00523	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.A247T	DMS-53	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.A247D	SIDM01173	Rhabdomyosarcoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.R266W	SIDM00773	Non-Cancerous	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00967	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00210	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00694	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00971	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00849	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00068	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00774	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM00785	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.R266W	SIDM01318	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.A244T	DMS-53	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 17 of 17 entries

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Drug responses associated with ADGRG2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PFSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...

Showing 1 to 25 of 30 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with ADGRG2 mutations

All proteins holding degron of PFSSS