DegronMD - O14526(FCHO1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P416A	TCGA-BA-6869	HNSC	TCGA	PRTSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.6392
p.E423Q	TCGA-E2-A10C	BRCA	TCGA	PRTSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.25
p.E423Q	DO1334	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.25
p.H453L	DO228928	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.G463V	DO229029	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7532
p.A415S	DO229031	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	416:420	Mutation rewiring degron network	0.3056
p.A484G	DO222662	MELA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.1944
p.P487T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.1111
p.P487T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.1111
p.S467L	SIDM00630	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7667
p.S467L	MDA-MB-415	breast	COSMIC	PFSSS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7667
p.P489R	SIDM00056	Thyroid Gland Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.0556
p.P489R	ACH-002148	Thyroid Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.0556
p.P489R	K5	thyroid	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation rewiring degron network	0.0556
p.D478N	ACH-000018	Bladder Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation altering degron motif	0.5821
p.S474L	MDA-MB-415	breast	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	474:479	Mutation altering degron motif	0.7667
p.S417L	MDA-MB-415	breast	COSMIC	PRTSS	DEG_SPOP_SBC_1	416:420	Mutation altering degron motif	0.7667

Kaplan plot for FCHO1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCHO1

UniProt ID: O14526

Entrez ID: 23149

Protein name: F-BAR domain only protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FCHO1 in